O'PKANING METASTATIK O'SMALARIDA CK7 VA TTF-1 MARKERLARINING AHAMIYATI
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o'pka saratoni, immunohistokimyo, CK7, TTF-1##article.abstract##
Ushbu maqolada o'smalarning tabiati va kelib chiqishini aniqlashning muhim usullaridan va diagnostikasidan biri bolgan CK7 va TTF-1 onkomarkerlaridan foydalangan holda biopsiya namunalaridan immunogizitokimyoviy tahlil qilinib, ularning birlamchi yoki metastatik o'pka adenokarsinomalarida mansubligini aniqlashdan iborat.
Tadqiqot maqsadi. Birlamchi va metastatik o'pka adenokarsinomalarining CK7 va TTF-1 bo'yalishining tabiatini aniqlash, shuningdek metastatik osmalarning lokalizatsiyasini aniqlash.
Materiallar va tadqiqot usullari. OvaPRIIAM Samarqand filiali o‘simta kelib chiqishining birlamchi lokalizatsiyasini aniqlash maqsadida gistologik tashxis qo‘yilgan 6 nafar bemordan olingan o‘pka biopsiya namunalari tadqiqot materiali bo‘lib xizmat qildi. Tadqiqotda quyidagi birlamchi VENTANA antitelolari ishlatilgan: quyon monoklonal antitelolari CONFIRM anti-Cytokeratin 7 (SP52); sichqonning monoklonal antitelolari Qalqonsimon bezga qarshi transkripsiya faktor-1 (8G7G3/1).
Tadqiqot natijalari. 20 ta namunadan 50% hollarda (20 tadan 10 tasi) CK7 pozitiv bo'yalishi o'pka adenokarsinomasini tavsiflaydi va ajratadi. TTF-1 bo'yash namunasi 20 ta namunaning 30 foizida (20 tadan 6 tasi) o'pka adenokarsinomasini farqladi.
Xulosa. Shunday qilib, shuni ta'kidlash kerakki, bizning tadqiqotimizda CK7 pozitiv kesmalar adenokarsinomaning barcha holatlarida ifodalangan. TTF-1ning namoyon bo'lishi o'pka saratonining gistologik turlari va / yoki differentsiatsiyasi bilan bog'liq. Bundan tashqari TTF-1 pozitiv kasmalarning barchasida adenokarsinomalar qayd etilgan va skuamoz muguzlanmaydigan karsinomalarda o'simta hujayralarida aniqlanmagan.
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