ITZENKO-KUSHING SINDROMIDA IKKI TARAFLI ADRENALEKTOMİYA UCHUN BIZNING TAJRIBAMIZ
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Itsenko-Kushing sindromi, ikki tomonlama adrenalektomiya, transsfenoidal adenomektomiya, ektopik Kushing sindromi, ikki tomonlama kortikosteroma##article.abstract##
Maqsad: Itsenko-Kushing sindromi uchun ikki tomonlama adrenalektomiya natijalarini tahlil qilish. Materiallar va usullar. Tahlil qilingan 16 ta ikki tomonlama adrenalektomiya (AE) holatlaridan 14 tasida bosqichma-bosqich amalga oshirildi (11 ta holatda muvaffaqiyatsiz transsfenoidal adenomektomiyadan so'ng Itsenko-Kushing kasalligi, 2 tasida - ektopik Kushing sindromi (EKS) bilan), 1 tasida - ikki tomonlama kortikosteroma bilan) va ikkita holatda - bir vaqtning o'zida (ikki tomonlama kortikosteroma bilan 2 holatda). Bemorlarning yoshi o'rtacha 30,14±4,13 (20-38) yosh, erkaklar va ayollar nisbati 1:1,7. 4 holatda AE transabdominal, 28 holatda retroperitoneoskopik usulda amalga oshirildi. Natijalar. O'rtacha kuzatuv davri 35,5 oyni tashkil etdi. AE dan keyin
bemorlarning katta qismi (75%) ortiqcha vaznni 8yo'qotdi va BMI <25 (P <0,001) ga erishdi. Arterial gipertenziyada statistik jihatdan sezilarli yaxshilanish ham kuzatildi (93,75% dan 50% gacha) (P <0,005). Operatsiyadan oldin 56,25% qandli diabet bilan kasallangan, operatsiyadan keyin esa 18,5%. Bemorlarning 25 foizida o'tkir adrenal etishmovchilik rivojlangan. Kuzatuv davrida o'lim 18,75% hollarda kuzatilgan. Xulosa. Ikki tomonlama AE SIC bilan og'rigan bemorlarda giperkortizolizm ko'rinishlarini davolashning samarali usuli hisoblanadi. Bu muvaffaqiyatsiz TAE va ESIC bilan DIC uchun yaxshi palliativ davolashni ta'minlaydi. Ko'pgina bemorlar yaxshi omon qolish va yaxshi hayot sifatiga ega. Operatsiyadan keyingi davrda o'lim ko'rsatkichi operatsiyadan oldingi davrda yuzaga keladigan asoratlarning og'irligiga bevosita bog'liq.
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