YOSHLARDAGI ISHEMIK INSULTNI RIVOJLANISHDA BDNF NING AHAMIYATI
##article.subject##:
ishemik insult, yoshlar, patogenetik subtiplar, miya neyrotrofik omil, NIHSS##article.abstract##
Maqsad: yoshlarda o'tkir ishemik insultning rivojlanish chastotasi bilan miya neyrotrofik omil darajasining o'zaro bog'liqligini o'rganish
Material va metodlar: Tadqiqotga o'tkir ishemik insultni boshdan kechirgan 22-44 yoshdagi 83 bemor (asosiy guruh) (erkaklar 41 (49,4%), ayollar 42 (50,6%); o'rtacha yoshi 38,71±6,5 yosh) kiritilgan. Nazorat guruhi yoshi va jinsi bo'yicha mos taqqoslanadigan 54 nafar sog'lom kishidan iborat edi (erkaklar 31 (57,4%), ayollar 23 (42,6%); o'rtacha yoshi 38,59±6,64 yosh). Miya neyrotrofik omilini (BDNF) miqdoriy aniqlash ferment bilan bog'liq immunosorbent tahlil usuli bilan amalga oshirildi.
Natijalar: Yuqoridagi jadvalda keltirilgan ma'lumotlarni sinchkovlik bilan o'rganib chiqib, biomarker kontsentratsiyasining kasallikning og'irligi va nevrologik simptomlarning og'irligi bilan teskari korrelyatsiya aloqasi aniqlandi. NIHSS shkalasi bo'yicha nevrologik kasalliklarning yengil kechishi bo'lgan bemorlarda biz zardobdagi BDNF ning yuqori konsentratsiyasini kuzatdik va aksincha, uning darajasining pasayishi nevrologik yetishmovchilikning o'ta og'ir darajasi bo'lgan bemorlarda aniqlandi (r =-0.137, p<0.05). Bemorlarda zardobdagi BDNF miqdorini aniqlash uchun guruh ichidagi tahlilni o'tkazilganda, ishemik insultning patogenetik kichik turiga qarab, neyrotrofin darajasining nevrologik kasalliklarning og'irligi bilan bog'liqligi aniqlandi, bunda gemodinamik insult bilan og'rigan bemorlarda ushbu biomarker darajasining eng past ko'rsatkichi kuzatildi.
Xulosa: BDNF qiymatlari eng past bo'lgan bemorlarda ishemik insultning salbiy natijasi xavfi ortadi va reabilitatsiya potentsialining darajasi pasasayadi, shu bilan birga miyada ushbu markerning ko'payishi yo'qolgan funktsiyalarni tiklashga yordam beradi.
Библиографические ссылки
Umirova S. M., Sabirova Sh. B. The use of neuroprotectors in restoring motor functions in patients after ischemic stroke //Ukraine. Health of the nation.2020;2(3):171-173 (in Russ)
Mavlyanova Z. F., Kulmirzaeva Kh. I. Clinical and neuroimaging picture of ischemic stroke in the acute period // Bulletin of the Kazakh National Medical University. 2015;2:87-89 (in Russ)
Kim O. A., Dzhurabekova A. T. Comparative aspect of the etiopathogenesis of ischemic stroke at a young age //Science and practice: Implementation to Modern society Proceedings of the 5th International Scientific and Practical Conference MANCHESTER, GREAT BRITAIN. 2020;2628:177-180
Garg A. et al. Differential risk factors and outcomes of ischemic stroke due to cervical artery dissection in young adults //Cerebrovascular Diseases. 2020;49(5):509-515
Renna R. et al. Risk factor and etiology analysis of ischemic stroke in young adult patients //Journal of stroke and cerebrovascular diseases. 2014;23(3):e221-e227.
Putaala J. Ischemic stroke in the young: Current perspectives on incidence, risk factors, and cardiovascular prognosis. Eur Stroke J. 2016 Mar;1(1):28-40.
Yoon CW, Park HK, Rha JH. Yield of Screening Tests for Systemic Vasculitis in Young Adults with Ischemic Stroke. Eur Neurol. 2018;80(5-6):245-248
Begidova N. M. Stroke in young people in the Kabardino-Balkarian Republic: dis. – GOUVPO "Russian State Medical University", 2009 (in Russ)
Chapaeva N.N., Terekhova A.B., Shishkin S.V., Duma S.N., Bakhareva Y.S., Mikhailenko O.I., Aidagulova S.V., Terekhova A.B., Demin A .A. Study of the etiopathogenesis of ischemic stroke in young patients. Medical Sciences. 2013;4:1-9 (in Russ)
Zavaliy L.B., Petrikov S.S., Shchegolev A.V. Metabolic therapy for ischemic stroke. Journal named after N.V. Sklifosovsky "Emergency medical care"». 2018; 7(1):44-52 (in Russ)
Anatolevna K. I. M. O. ETIOPATHOGENETIC AND CLINICAL-NEUROLOGICAL CHARACTERISTICS OF ISCHEMIC STROKE IN YOUNG PEOPLE DEPENDING ON HETEROGENEITY //JOURNAL OF BIOMEDICINE AND PRACTICE.2023;8(1) (in Uzb)
Balkaya M., Cho S. Genetics of stroke recovery: BDNF val66met polymorphism in stroke recovery and its interaction with aging //Neurobiology of disease. 2019;126:36-46.
Braun R. G. et al. Effects of the BDNF Val66Met polymorphism on functional status and disability in young stroke patients //Plos one. 2020;15(12):0237033
Stanne T. M. et al. Low circulating acute brain-derived neurotrophic factor levels are associated with poor long-term functional outcome after ischemic stroke //Stroke.2016;47(7):1943-1945.
Lasek-Bal A. et al. Low concentration of BDNF in the acute phase of ischemic stroke as a factor in poor prognosis in terms of functional status of patients //Medical science monitor: international medical journal of experimental and clinical research. 2015;21:3900.
Novikova L.B., Akopyan A.P., Sharapova K.M., Kolchina E.M., Girfanova A.M., Yasinskaya A.S. Insulty u litz molodogo vozrasta//Vestnik Bashkirskogo gosudarstvennogo meditsinskogo universiteta. 2017;S2:1051-1056 (in Russ)
Simonetti, B.G., Mono, M., Huynh-Do, U. et al. Erratum to: Risk factors, aetiology and outcome of ischaemic stroke in young adults: the Swiss Young Stroke Study (SYSS). J Neurol. 2016;263: 199–200.
Saengen AK, Christenson RN. Stroke Biomarkers: Progress and Challenges for Diagnosis, Prognosis, Differentiation and Treatment//Clin. Chem. 2010;56(1):21-33
Kim O., Djurabekova A., Urunov D. ROLE OF BIOMARKERS OF RISK OF ISCHEMIC STROKE IN YOUNG PEOPLE // Journal of the Doctor's Bulletin. 2021;1(2):47-50 (in Russ)
Статья поступила в редакцию 05.01.2024; одобрена после рецензирования 18.02.2024; принята к публикации 20.02.2024.
The article was submitted 05.01.2024; approved after reviewing 18.02.2024; accepted for publication 20.02.2024.
Информация об авторах:
Ким Ольга Анатольевна - PhD, ассистент кафедры медицинской реабилитации, спортивной медицины и народной медицины. Самаркандский государственный медицинский университет, Самарканд, Узбекистан. Е-mail: olanten@mail.ru, https://orcid.org/0000-0003-1987-9505
Источники финансирования: Работа не имела специального финансирования.
Конфликт интересов: Авторы декларируют отсутствие явных и потенциальных конфликтов интересов, связанных с публикацией настоящей статьи.
Вклад авторов:
Ким О.А. - идеологическая концепция работы, анализ источников литературы, сбор материала, написание текста, редактирование статьи
Information about the authors:
Kim A. Olga – PhD, assistant of the department of medical rehabilitation, sports medicine and folk medicine. Samarkand state medical university. Samarkand, Uzbekistan; Е-mail: olanten@mail.ru, https://orcid.org/0000-0003-1987-9505
Sources of funding: The work did not receive any specific funding.
Conflict of interest: The author declare no explicit or potential conflicts of interest associated with the publication of this article.
Contribution of the author:
Kim O.A. - ideological concept of work, analysis of literature sources, collecting material, writing text, editing the article.
