O‘G‘IL BOLALARDA JINSIY YETILISHNING KECHIKISHI: DIAGNOS TIKA VA DAVOLASHNING ZAMONAVIY YONDASHUVLARI
##article.subject##:
jinsiy rivojlanishning kechikishi, ingibin B, antimyuller gormoni, gipogonadizm, Sertoli hujayralari, fertillik, pubertat##article.abstract##
O‘g‘il bolalarda jinsiy rivojlanishning kechikishi (JRK) – bu pediatriya va o‘smirlar endokrinologiyasida dolzarb va ko‘p tarmoqli muammo bo‘lib, aniq diagnostika va individual yondashuvni talab qiladi. Ushbu sharhda ingibin B va antimyuller gormoni (AMG) Sertoli hujayralari funksiyasining markerlari sifatida JRK dagi o‘rni haqidagi zamonaviy ilmiy ma’lumotlar umumlashtirilgan. Ularning sekretsiya mexanizmlari, fiziologik rollari, turli yosh bosqichlaridagi dinamikasi hamda JRK konstitutsional shakli bilan gipogonadizmni farqlashdagi diagnostik va prognostik ahamiyati ko‘rib chiqilgan. Ingibin B va AMG darajalari bilan an’anaviy gormonal ko‘rsatkichlar (LG, FSG, testosteron) hamda fertilitet o‘rtasidagi bog‘liqlik tahlil qilingan. Ushbu markerlardan erta diagnostika, jinsiy yetilishning prognozi va o‘smir erkaklarda reproduktiv salohiyatni baholashdagi istiqbollar muhokama etilgan. Ingibin B va AMG ni JRK holatlarini baholash algoritmlariga kiritish diagnostik aniqlikni oshirish va davolash taktikalarini optimallashtirish uchun maqsadga muvofiq deb hisoblanadi.
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