EKSPERIMENTAL TIROTOKSIKOZLI KALAMUSHLARDA JIGARNING METABOLIK-FUNKTSIONAL HOLATIGA CRAMBE KOTSCHYANA EKSTRAKTINING MODULLASH TA'SIRI
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экспериментальный тиреотоксикоз, экстракт Сrambe кotschyana, мерказолил, гепатодисфункция##article.abstract##
Qalqonsimon bez va jigar a’zolari ham fiziologik, ham patologik sharoitda murakkab munosabatlarda uchraydi. Tirotoksikozda jigar patologiyasi paydo bo’lishi juda keng tarqalgan (15-79%) va bu sitoliz /yoki xolestaz fermentlarining qon zardobida faolligining oshishi bilan namoyon bo'ladi.
Tadqiqotning maqsadi: eksperimental tirotoksikoz chaqirilgan hayvonlar jigarning metabolik-funktsional holatiga Crambe kotschyana Boiss ekstraktining merkazolil bilan taqqoslagan xolda kiritilishi fonida tasirini o'rganish.
Tadqiqot materiallari va usullari: tajribada levotiroksin natriyni 50 mkg/kg dozada og'iz orqali yuborish natijasida tirotoksikoz chaqirilgan erkak kalamushlar (160-180 g) ishlatilgan. Hayvonlarning qon zardobida erkin triyodtironin, erkin tetrayodtironin va tireotrop gormon darajasi, shuningdek alanin va aspartat aminotransferaza, ishqoriy fosfataza fermentlarining faolligi va oqsilning umumiy miqdori, jigar to'qimalarida glikogen va malon dialdegid miqdori aniqlandi.
Natijalar: eksperimental tirotoksikoz og'ir gepatodisfunktsiya bilan namoyon bo’ldi. Bu AlAT, AsAT va ishqoriy fosfataza fermentlari faolligining sezilarli darajada oshishi, MDA darajasining oshishi, shuningdek, sitoliz, xolestazning rivojlanishi va oksidlovchi stressning kuchayishini aks ettiruvchi glikogen va umumiy oqsil miqdorining pasayishi bilan tasdiqlandi. Bunday sharoitda Crambe kotschyana ekstrakti jigar to'qimalariga yumshoqroq va fiziologik ta'sir ko'rsatdi, oksidlovchi stressning namoyon bo'lishini samaraliroq kamaytirdi va tirotoksikoz tufayli kelib chiqadigan buzilishlarni qisman tuzatishga qaramay, jigarning energiya zaxiralarini yaxshiroq tiklashga yordam berdi va o'ziga xos gepatotoksiklik faollikni ko'rsatdi.
Xulosa: olingan ma'lumotlar shunu ko’rsatadiki tireogenik gipermetabolik yuk ostida jigar tomonidan aniq buzilishlarni paydo bo’ladi va C. kotschyana ekstraktining korreksiyalash faolligi an'anaviy tireostatik merkazolil bilan solishtirish imkonini beradi.
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