INSULINREZISTENTLIK VA SUBKLINIK YALLIG‘LANISHNING GESTATSION QANDLI DIABETDAGI O‘RNI: PREEKLAMPSIYA RIVOJLANISHI BILAN BOG‘LIQLIGI
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gestatsion qandli diabet, preeklampsiya, insulinrezistentlik, HOMA-IR, C-reaktiv oqsil, ferritin, tana vazni indeksi##article.abstract##
Dolzarblik: Gestatsion qandli diabet (GQD) preeklampsiya rivojlanishining muhim xavf omillaridan biri hisoblanadi. Biroq GQD aniqlangan homilador ayollarda insulinrezistentlik va subklinik yallig‘lanish ko‘rsatkichlarining preeklampsiyani prognoz qilishdagi ahamiyati yetarli darajada o‘rganilmagan.
Maqsad: Gestatsion qandli diabet bilan og‘rigan homilador ayollarda insulinrezistentlik va subklinik yallig‘lanish ko‘rsatkichlarining preeklampsiya rivojlanishi bilan bog‘liqligini hamda ularning prognostik ahamiyatini baholash.
Materiallar va usullari: O‘zbekiston Respublikasining 6 hududida o‘tkazilgan ko‘p markazli skrining tadqiqoti doirasida aniqlangan 192 nafar GQDli homilador ayollar ma’lumotlari retrospektiv tahlil qilindi. Tana vazni indeksi (TVI), insulin, HOMA-IR indeksi, C-reaktiv oqsil (CRO) va ferritin darajalari baholandi. Statistik tahlilda korrelyatsion tahlil, odds ratio hisoblash va ROC-tahlil usullaridan foydalanildi.
Natijalar: Preeklampsiya 192 nafar bemordan 10 tasida (5,2%) rivojlandi. Preeklampsiya rivojlangan ayollarda TVI, HOMA-IR, CRO va ferritin ko‘rsatkichlari preeklampsiyasiz ayollarga nisbatan sezilarli darajada yuqori bo‘ldi (p<0,05). CRO (AUC=0,790) eng yuqori prognostik qiymatni namoyish etdi. HOMA-IR, CRO va ferritinning kombinatsiyalangan modeli yuqori prognostik samaradorlikka ega bo‘lib, AUC 0,817 ni tashkil etdi.
Xulosa: Gestatsion qandli diabetda preeklampsiya rivojlanishi insulinrezistentlik va subklinik yallig‘lanishning kuchayishi bilan bog‘liq. HOMA-IR, CRO va ferritinning kompleks baholanishi preeklampsiya xavfi yuqori bo‘lgan homilador ayollarni aniqlash imkonini beradi va akusherlik kuzatuvini optimallashtirish uchun istiqbolli yondashuv hisoblanadi.
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