«ОСОБЕННОСТИ ГОРМОНАЛЬНЫХ И ИММУННОЛОГИЧЕСКИХ НАРУШЕНИЙ У ПАЦИЕНТОВ С АУТОИММУННЫМ ПОЛИГЛАНДУЛЯРНЫМ СИНДРОМОМ»
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Maqsad – autoimmunn polyglandular syndrom bilan kasallangan bemorlarda gormonal va immunologik kasalliklarning xususiyatlarini o'rganish (APS)
Material va tadqiqot usullari. APS turi bo'lgan 258 ta endokrin bezlarga zarar etkazgan holda ko'rikdan o'tkazildi. Bemorlarning quyidagi uchta kichik guruhlari shakllanadi: 1 gr.: 1a gr. - Qandli diabet bilan og'rigan bemorlar, 1 mln. - 32, 1b. Gr.
Barcha bemorlar umumiy klinik, biokimyoviy, gormonal (AKTG, TTG, kortizol, DGEA, insulin, thyroxin), Ichki organlarning ultratovushlari, rentgenologik tadqiqotlar, Radiologik tadqiqotlar, ultratovush olib boradigan barcha tadqiqotlar olib borildi tor mutaxassislar, shuningdek statistik usullar. Immunologik tadqiqot usullari, qon tomirlaridan antitelo qalqonsimon bezga, buyrak usti bezi va meda osti beziga nisbatan aniklandi.
Tadqiqotlar natijalari. 18 yoshdan 44 yoshgacha bo'lgan bemorlar, erkaklar va ayollar orasida - 58/35 ishi.
Bemorlarda 1 guruhda, GA / IA-2 miqdori oshganligi 16,7 ± 1.09 iU / ml (P <0.05) aniklandi. 1b guruhidagi Р450с21 ga nisbatan antitelolarning oshishi 23 bemorda aniklandi (72%). 1- v guruhida esa bemorlarda antitelo 26,8 ± 2.02 iU / ml ishonchli qilingan (p <0, 05) ).
P450S21 bilan og'rigan bemorlarga antikorlarni o'rganish 23 (72%) bo'lgan bemorlarga antikorlar p450s21-ga qarshi og'rigan bemorlarda Р450с21 ga nisbatan antitelolar aniqlanmadi. Taqqoslash guruhida p450s21 aniqlandi.
Xulosa. 1. Bemorni kompensatsiya qilish darajasini individual baholash darajasida 1 tur qandli diabet, AIT va surunkali buyrak etishmovchiligi (SBE) dastlabki tashxis qo'yishda muhim ahamiyatga ega va ushbu toifadagi bemorlarning general protokoliga kiritilishi kerak.
2. Antitelolarni P450S21-ga o'rganish, birlamchi SBE diagnostikasi bo'yicha o'rganish, ayniqsa sil kasalligi genezisining tashxisiga ega
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