CLINICAL AND LABORATORY FEATURES OF CONNECTIVE TISSUE DYPLASIA IN PATIENTS WITH UPPER GIT PATHOLOGY
Keywords:
pathologies of the upper gastrointestinal tract, connective tissue dysplasia, endothelial dysfunction, extracellular matrixAbstract
The aim of the study was to study the state of endothelial function, connective tissue metabolism in patients with pathology of the upper gastrointestinal tract against the background of connective tissue dysplasia in order to develop a system for managing patients at the level of primary health care. As a result of the study, it was found that patients with pathology of the gastrointestinal tract associated with CTD had a decrease in the level of magnesium in the blood, activation of hyaluronidase, which contributed to an increased breakdown of the components of the extracellular matrix with an increase in the excretion of their decay products. Endothelial dysfunction is also noted, due to an imbalance in the NO system. The imbalance in the NO system, in turn, is determined by the overexpression of iNOS and the accumulation of ONO2-, inhibition of eNOS activity.
References
Bataev X.M. Birlashtiruvchi to'qima displazi namoyon bo'lgan o'smirlarda gastroezofagial reflyuks kasalligi: immunologik jihatlar. / Bataev X.M., Shixnabieva M.D. // Dog'iston davlat tibbiyot akademiyasining xabarnomasi. - 2016 yil. 1-son (18). - S. 17 - 20.
Zemtsovskiy E.V. Yurakning kichik anomaliyalari va displastik fenotiplar / E.V. Zemtsovskiy, E.G. Malev // Sankt-Peterburg: "IVESEP" nashriyoti, 2011. - P.160.
Kononov A.V. Surunkali gastrit fenotipining asosi sifatida oshqozon shilliq qavatining atrofiyasi morfogenezi / A. V. Kononov, S. I. Mozgovoy, M. V. Markelova, A. G. Shimanskaya // Arch. Pat. - 2011. - Nashr. 3. - S. 26-31.
Birlashtiruvchi to'qima displazi bilan kasallangan bemorlarni tashxislash, davolash va reabilitatsiya qilish bo'yicha milliy ko'rsatmalar. Ed. A.I. Matynova, G.I. Nechaeva. M.: Bionika Media MChJ, 2016. S. 12.
Sablina O.F. Birlashtiruvchi to'qima displazi bilan oshqozon shilliq qavatida atrofik jarayonning klinik va strukturaviy ko'rinishlarining xususiyatlari / L.A. Naumova, O.F. Sablina, E.E. Chichagova // Yaroslav Donishmand nomidagi Novgorod davlat universitetining xabarnomasi. "Tibbiyot fanlari" seriyasi. - 2011. - No 66. - B. 83–87.
Chernuxa S.N. Differentsiatsiyalanmagan biriktiruvchi to'qima displaziyasi bo'lgan bemorlarda atrofik gastritni davolash xususiyatlari / S. N. Chernuxa. - Matn: to'g'ridan-to'g'ri // Yosh olim. - 2014. - No 10 (69). - S. 94-97.
Shixnabieva M.D., Bataev X.M., 2014. Birlashtiruvchi to'qima displazi va uning ovqat hazm qilish tizimi patologiyasini rivojlanishidagi o'rni. // Doktor. - 2014 yil. - 2-son. - S. 7 - 9.
Shodiqulova G.Z., Babamurodova Z.B. Differentsiatsiyalanmagan biriktiruvchi to‘qima displaziyasida kollagenlarga ba’zi avtoantikorlarning klinik-diagnostik ahamiyati // Yevroosiyo shifokorlar assotsiatsiyasining IV Kongressi O‘zbekiston vrachlarining Respublika ilmiy-amaliy konferensiyasi bilan birgalikda. – Toshkent, 2018. – B.31
Shodiqulova G.Z. Klinik laboratoriya parametrlari va ularning UCTDdagi magniy darajalari bilan bog'liqligi. "Fan va ta'lim yutuqlari" Rossiya, 2019 yil No 10 (51), 41-45-betlar.
Goldenring JR Oksintik atrofiya, metaplaziya va oshqozon saratoni / JR Goldenring, KT Nam // Prog. Mol. Biol. Tarjima. fan. - 2010. - jild. 96. - B. 117-131.
Salis G., 2011. Tizimli tahlil: Lotin Amerikasida gastroezofagial reflyuks kasalligi epidemiologiyasi. Acta Gastroenterol Latinoam V.41 (1). B. 60-69.
Shodiqulova G.Z., Mirzaev O.V., Babamurodova Z.B. Oʻzbek populyatsiyasida differensiallanmagan biriktiruvchi toʻqima displaziyasining klinik variantlari tarqalishi// “YEVROPA TADQIQOTLARI: fan, taʼlim va texnologiyadagi innovatsiyalar” LXIV xalqaro sirtqi ilmiy-amaliy konferensiyasi/ - London, Buyuk Britaniya, 2020 yil. - R. 90-92.
Gulandom Shodiqulova, Dilshod Samatov, Zarangis Tairova
Patologiyaning klinik kechishi va diagnostikasining o'ziga xos xususiyatlari
biriktiruvchi to'qima displaziyasi bo'lgan bemorlarda yuqori oshqozon-ichak trakti //Biotibbiyot va amaliyot jurnali.-2021.-№1.s.160-166.
Shodikulova G. Z. et al. Evaluation of Endothelial Function and Connective Tissue Metabolism in Patients with Upper Git Pathology on the Background of Connective Tissue Dyplasia //Telematique. – 2022. – С. 6874–6880-6874–6880.
Shodikulova G. Z. et al. CLINICAL AND LABORATORY FEATURES OF THE COURSE OF UPPER GASTROINTESTINAL PATHOLOGY WITH CONNECTIVE TISSUE DYSPLASIA //Confrencea. – 2022. – Т. 6. – №. 6. – С. 118-119.
Shodikulova G. Z. et al. EVALUATION OF ENDOTHELIAL FUNCTION AND ANTIOXIDANT SYSTEM IN PATIENTS WITH PATHOLOGY OF THE UPPER GASTROINTESTINAL TRACT WITH CONNECTIVE TISSUE DYSPLASIA //Confrencea. – 2022. – Т. 6. – №. 6. – С. 83-86.
Shodikulova G. Z., Samatov D. K. PECULIARITIES OF CLINICAL PICTURE IN PATIENTS WITH UPPER GASTROINTESTINAL PATHOLOGY WITH CONNECTIVE TISSUE DYSPLASIA SYNDROME //Frontline Medical Sciences and Pharmaceutical Journal. – 2022. – Т. 2. – №. 02. – С. 43-49.
Саматов Д. К. и др. БИРИКТИРУВЧИ ТЎҚИМА ДИСПЛАЗИЯСИ ВА ЮҚОРИ ОШҚОЗОН-ИЧАК ТРАКТИ ЮҚОРИ ҚИСМИ ПАТОЛОГИЯСИ БЎЛГАН БЕМОРЛАРДА ЭНДОТЕЛИАЛ ВА ҲУЖАЙРАДАН ТАШҚАРИ МАТРИЦА ДИСФУНКЦИЯСИНИНГ МАРКЕРЛАРИ //SCIENTIFIC ASPECTS AND TRENDS IN THE FIELD OF SCIENTIFIC RESEARCH. – 2023. – Т. 1. – №. 8. – С. 141-153.
Мирзаев О. В. и др. ОСОБЕННОСТИ ВАРИАБЕЛЬНОСТИ СЕРДЕЧНОГО РИТМА У ЛИЦ ДИСПЛАЗИЕЙ СОЕДИНИТЕЛЬНОЙ ТКАНИ //SCIENTIFIC ASPECTS AND TRENDS IN THE FIELD OF SCIENTIFIC RESEARCH. – 2023. – Т. 1. – №. 8. – С. 196-213.
Мирзаев О. В. и др. ОСОБЕННОСТИ КЛИНИЧЕСКОГО ТЕЧЕНИЯ И ДИАГНОСТИКИ НАРУШЕНИЯ РИТМА СЕРДЦА У МОЛОДЫХ ПАЦИЕНТОВ С ДИСПЛАЗИЕЙ СОЕДИНИТЕЛЬНОЙ ТКАНИ //SCIENTIFIC ASPECTS AND TRENDS IN THE FIELD OF SCIENTIFIC RESEARCH. – 2023. – Т. 1. – №. 8. – С. 121-131.
