IMMUNOHISTOCHEMICAL CHANGES IN LYMPH NODES IN PREGNANT WOMEN WHO DIED OF COVID-19
Keywords:
COVID-19, pathogenesis, pathomorphology, lymph nodes, immunohistochemistry, endothelial damage, pregnancyAbstract
The pathogenesis of the new coronavirus infection COVID-19 is under active study. Nevertheless, information on changes in the lymphoid tissue in the secondary organs of the immune system, accompanying the severe course of the disease, especially in pregnant women remains extremely limited. The aim of the study was to study the histological and immunomorphological changes in the lymph nodes of deceased patients with severe COVID-19.
References
Fedorov DN, Korosteleva PA, Zybin DI, Popov MA, Tyurina VM, Varlamov AV. Morphological and immunohistochemical characterization of changes in lymph nodes of bronchopulmonary group in patients with new coronavirus infection COVID-19 (based on autopsy studies). Almanac of Clinical Medicine. 2020;48:37-42.
Park WB, Kwon NJ, Choi SJ, Kang CK, Choe PG, Kim JY, Yun J, Lee GW, Seong MW, Kim NJ, Seo JS, Oh MD. Virus Isolation from the First Patient with SARS-CoV-2 in Korea. J Korean Med Sci. 2020;35(7):e84. doi: 10.3346/jkms.2020.35. e84.
Hoffmann M, Kleine-Weber H, Schroeder S, Krüger N, Herrler T, Erichsen S, Schiergens TS, Herrler G, Wu NH, Nitsche A, Müller MA, Drosten C, Pöhlmann S. SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor. Cell. 2020;181(2):271–80.e8. doi: 10.1016/j. cell.2020.02.052.
Wang K, Chen W, Zhou YS, Lian JQ, Zhang Z, Du P, Gong L, Zhang Y, Cui HY, Geng JJ, Wang B, Sun XX, Wang CF, Yang X. SARS-CoV-2 invades host cells via a novel route: CD147-spike protein [Internet]. bioRxiv. 2020 Mar. doi: 10.1101/2020.03.14.988345.
Walls AC, Park YJ, Tortorici MA, Wall A, McGuire AT, Veesler D. Structure, Function, and Antigenicity of the SARS-CoV-2 Spike Glycoprotein. Cell. 2020;181(2):281–92.e6. doi: 10.1016/j.cell.2020.02.058.
Perrella A, Trama U, Bernardi FF, Russo G, Monastra L, Fragranza F, Orlando V, Co. Brancatella A, Ricci D, Viola N, et al. Subacute thyroiditis after SARS-CoV-2 infection. J Clin Endocrinol Metab. 2020;105(7):dgaa276. https://doi.org/10.1210/clinem/dgaa276.