CLINICAL-LABORATORY AND FERROKINETIC FEATURES IN CHILDREN WITH CHRONIC GLOMERULONEPHRITIS

Abstract

This article is aimed to study clinical, laboratory and ferrokinetic features of the course of chronic glomerulonephritis (CGN) in children depending on the forms of the disease. Clinical-laboratory and ferrokinetic data were analyzed in 51 children with CGN at the age of 2 to 18 years undergoing hospital treatment at the nephrology department of the Republican Specialized Scientific and Practical Pediatrics Center. The prospective analysis was carried out in 24 children with nephrotic CGN, in 21 children with nephritic form, in 4 children with mixed form and in 2 children with isolated urinary syndrome. In the group of children under study, most cases were children with nephrotic form of CGN, it was the 1st group, and with nephritic form, which was the 2nd group. The control group consisted of 20 children without renal pathology. Predisposing factors of exacerbation of CH in children were: acute respiratory infections - 54,9%, hypothermia - 13,72% and exacerbation of ENT pathologies - 9,8%. Nephrotic form (47%) and nephritic form (21%) were the most frequent forms of CGN in the study group. In these forms of CGN, relapsing and transient variants of the course of the disease prevailed. Anemia in children with CGN developed in 68.8%; in the nephrotic form the ferrokinetic parameters in 85.7% had a pronounced difference from the control group than in the nephrotic form of CGN. Presence of microhematuria and arterial hypertension in the debut of nephrotic syndrome, absence of acute manifestation and cyclic course of nephritic variant determined the formation of primary chronic course of glomerulonephritis in children.