ATHEROSCLEROTIC LESION OF THE CORONARY ARTERIES IN PATIENTS WITH EARLY DEVELOPMENT OF ACUTE CORONARY SYNDROME
Keywords:
acute coronary syndrome, genes and hereditary factorAbstract
Аccording to the results of many studies, for most people, the inherited risk of CHD is the result of many small effect size genetic factors acting in combination with and along with environmental and lifestyle factors. Common genetic variants associated with CAD have been identified as a result of larger population studies of genomic associations in Genome-Wide Association Studies (GWAS) [1,10]. A number of studies demonstrate the association between polymorphisms rs3825807 of the ADAMTS7 gene, rs699947 of the VEGF-A gene, rs2891168 of the CDKN2B gene, rs1746048 of the CXCL12 gene, and rs3184504 of the SH2B3 gene with the risk of CHD [3,9].
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