EXPRESSION OF MICRORNA LEVELS IN INTESTINAL OBSTRUCTION IN CHILDREN

Abstract

MicroRNAs, a class of small non-coding RNA molecules with regulatory functions of genes, play a crucial role in the pathogenesis of various diseases. Current technological advances make it possible to determine the abundance of microRNAs in various tissues accurately and with high throughput [1, 2]. More recently, extracellular circulating microRNAs have begun to be demonstrated as highly stable biomarkers of diseases based on blood and feces [3, 5]. Understanding the interactions between circulating microRNAs and clinical phenotypes can expand our knowledge of complex diseases and traits. On the other hand, considering the advantages of using biomarkers based on blood and other biomaterials (for example, in feces), circulating microRNAs as biomarkers can improve both the diagnosis of diseases and their treatment. In particular, we reviewed the progress in identifying circulating microRNAs as biomarkers of intestinal obstruction in children. These studies have shown a promising future for the use of circulating microRNAs for the treatment of intestinal obstruction. MicroRNAs (microRNAs) are small non-coding RNAs that regulate gene expression post-transcriptionally [6]. Changes in microRNA expression have been reported in a number of intestinal diseases both in tissue samples and in readily available samples, such as stool. It is believed that pathogenic infections, diet, toxins and other environmental factors affect microRNA expression [5, 7]. However, changes in human microRNAs have yet to be thoroughly studied.