METILEN TETRADUKTAZA POLIMORFIZMI RETINA TOMIRLARI OBKLYUZIYASI UCHUN XAVF OMILI SIFATIDA (Adabiyotlar sharhi)
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genlar polimorfizmi, to‘r parda qon tomirlari okklyuziyasi, tashxis, gomotsistein##article.abstract##
Dolzarbligi. MTHFR faolligi bilan bog‘liq bo‘lgan va gipergomotsisteinemiya hamda epigenetik disregulyatsiyaga olib keladigan bir uglerodli almashinuvning buzilishi, ayniqsa an’anaviy yurak-qon tomir xavf omillari bo‘lmagan bemorlarda, to‘r parda qon tomirlarining okklyuziv shikastlanishlari patogenezida kam o‘rganilgan, ammo potensial asosiy bo‘g‘in hisoblanadi. Tadqiqotning maqsadi. To‘r parda qon tomirlari okklyuziyasining xavf omillarini o‘rganish. Natijalar. Tasdiqlangan gipergomotsisteinemiyada asosiy vazifa ehtimoliy sabablarni aniqlash va bartaraf etishdan iborat. Bularga folat kislotasi, B12 va B6 vitaminlari yetishmovchiligi, surunkali buyrak kasalliklari, ayrim dori vositalari va ovqatlanish omillari kiradi.
Xulosalar.MTHFR faolligi bilan bog‘liq bo‘lgan bir uglerodli metabolizmning buzilishi S-adenozilmetionin ishlab chiqarilishining pasayishiga va global gipometillanishning rivojlanishiga olib keladi, bu qon tomir endoteliysi genlari (eNOS, VEGF, ICAM-1) ekspressiyasining buzilishi va endoteliy disfunksiyasining rivojlanishi bilan birga keladi, bu to‘r parda qon tomirlarining okklyuziv shikastlanishlari patogenezida markaziy rol o‘ynaydi.
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