ЮРАК ЕТИШМОВЧИЛИГИ БИЛАН ДИАБЕТИК НЕФРОПАТИЯНИ ДАВОЛАШДА ЯНГИ ЁНДАШУВ
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сурункали буйрак касаллиги, 2-тоифа натрий-глюкоза котранспортер ингибиторлари.##article.abstract##
Сурункали буйрак касаллигининг (CКД) ривожланиши нафақат юрак-қон томир касалликларининг шаклланиши, балки сурункали юрак етишмовчилиги (ЧФ) учун ҳам хавф омилидир. Мақола CКД ва ЧФ билан оғриган беморларда натрий-глюкоза котранспортер тури 2 ингибиторлари (НГЛТ2) дан фойдаланиш муаммоси бўйича адабиётларни кўриб чиқишдир. Мақолада НГЛ-2 ингибиторларининг рено - ва кардиопротекция нурида таъсир қилиш механизмлари батафсил келтирилган. НГЛТ2 ингибиторларининг глюкозурик таъсиридан ташқари улар натриуретик ва диуретик таъсирга ега. НГЛ-2 ингибиторларининг таъсиридан бири қон босимини пасайтириш қобилиятидир. НГЛТ2-2 ингибиторларининг ренопротектив таъсирини тушунтирувчи яна бир таъсири гломеруляр филтрацияга таъсир қилади.
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