AYOLLAR REPRODUKTIV TIZIMINING BIRINCHI KO'P XARXATLI O'SMALARINI RIVOJLANISH CHASTOSLIGI
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metaxron o'smalar; birlamchi ko'p malign o'smalar; ayol jinsiy tizimining o'smalari; sinxron o'smalar##article.abstract##
Tadqiqotning maqsadi – ayol jinsiy tizimining birlamchi ko'p xavfli o'smalari bo'lgan bemorlarda sinxron va metaxron o'smalarning rivojlanish chastotasini, shuningdek turli xil saraton turlarining kombinatsiyasini o'rganishdir. Bu ushbu toifadagi bemorlarning tashxisini yaxshilash uchun dolzarbdir. Tadqiqotga ayollarning reproduktiv tizimiga ta'sir qiluvchi birlamchi ko'p xavfli o'smalari bo'lgan 80 bemor (kasallikning II-III klinik bosqichlari) ishtirok etdi. Ushbu tadqiqot bemorlarning 27,5 foizida sinxron, 72,5 foizida metaxron o'smalari borligi aniqlandi. Ko'krak bezi saratoni bilan og'rigan 38 bemorning 23,7 foizida ikkinchi ko'krakning sinxron saratoni, 7,9 foizida tuxumdon saratoni bor edi. Sinxron ko'krak saratoni birlamchi tuxumdon saratoni bilan og'rigan bemorlarning 22,7 foizida, bachadon saratoni bilan og'rigan bemorlarning 25,0 foizida va bachadon bo'yni saratoni bilan og'rigan bemorlarning 25,0 foizida aniqlangan. Ko‘krak bezi saratoni bilan og‘rigan bemorlarning 68,4 foizida, tuxumdon saratoni 77,3 foizida, bachadon saratoni 75,0 foizida, bachadon bo‘yni saratoni bilan og‘rigan bemorlarning 75,0 foizida metaxron o‘smalari aniqlangan. Ko'pincha metaxron o'smalar bemorlarning 44,8 foizida 6 oydan 1 yoshgacha va 1 yoshdan 2 yoshgacha bo'lgan davrda aniqlangan. Shunday qilib, ayol jinsiy tizimining har bir shishi boshqa saraton patologiyalarini rivojlanish xavfining ko'rsatkichi sifatida ko'rib chiqilishi kerak. Va samarali klinik monitoring ushbu turdagi bemorlarda bir nechta asosiy malign o'smalarning rivojlanishini erta kuzatish imkonini beradi.
Библиографические ссылки
Akulenko L.V. O nasledstvennom rake molochnoj zhelezy, jaichnikov i jendometrija (klinicheskaja lekcija) [On hereditary cancer of the breast, ovary and endometrium (Clinical lecture)] // Problemy reprodukcii [Problems of reproduction], 2004. N6. P.20-27. [in Russian].
Balenkov O.Yu., Yuldasheva D.Yu., Kireev G.V., Kamishov S.V. Study of cancer incidence among the population of Tashkent // Journal of Theoretical and Clinical Medicine No. 3. -2007. -P.90-92. [In Russian]
DE Luca A., Frusone F., Vergine M. et al. Breast cancer and multiple primary malignant tumors: Case report and review of the literature. In vivo // 2019. V.33. P.1313–1324. doi: 10.21873/invivo.11605.
De Luca A., Frusone F., Vergine M. et al. Breast Cancer and Multiple Primary Malignant Tumors: Case Report and Review of the Literature // In Vivo. 2019. V. 33. N4. P.1313-1324. doi:10.21873/invivo.11605
Fedorov V.E., Barsukov V.Yu., Popova T.N. et al. Osobennosti techenija i trudnosti diagnostiki mnozhestvennyh zlokachestvennyh novoobrazovanij [Features of the course and difficulties in the diagnosis of multiple malignant neoplasms] // Medicinskij al'manah [Medical almanac], 2011. N2. P.157-160. [in Russian].
FIGO Committee on Gynecologic Oncology. Revised FIGO staging for carcinoma of the vulva, cervix, and endometrium // Int. J. Gynecol. Obstet. 2009. V.105. N2. P.103-104.
FIGO Committee on Gynecologic Oncology. Revised FIGO staging for carcinoma of the cervix uteri // Int. J. Gynecol. Obstet. 2019. V.145. N1. P.129-135.
International Union Against Cancer (UICC). TNM Classification of Malignant Tumours, 7th ed. Sobin L.H., Gospodarowicz M.K., Wittekind Ch., eds. New York: Wiley-Blackwell; 2009.
Kamishov S.V. Modern immunopharmacotherapy in the complex treatment of cervical cancer // Bulletin of Science and Education. 2018;2 (6), 42
Kamishov S.V., Tillyashaikhov M.N. The Effect of Extracorporeal Immunopharmacotherapy on Intracellular Metabolism in Cervical Cancer Patients // Клиническая и экспериментальная онкология, 2019:11-21.
Kamishov S.V., Pulatov D.A., Yuldasheva N.Sh. Studying the role of molecular biological tumor markers in the choice of immunotherapy method in the accompanying treatment of ovarian and cervical cancer // Eurasian Journal of Oncology. 2015;5(2):53-60. [In Russian]
Kamishov S.V., Yuldasheva N.S., Pulatov D.A. Supportive immunotherapy in complex treatment of patiens with oncogynaecological diseases Bulletin of Science and Education. 2013:158-161 [In Russian]
Kamishov S.V., Yuldasheva N.Sh., Salimova L.R. Study of methods of extracorporeal immunopharmacotherapy as an accompaniment to chemotherapy in patients with ovarian cancer // Oncology and Radiology of Kazakhstan 2010;16 (3-4):96 [In Russian]
Kamishov SV Modern immunopharmacotherapy in the complex treatment of cervical cancer. Bulletin of Science and Education. 2018;2;6(42):57-61. [In Russian].
Kamishov SV, Pulatov DA, Yusupova NB, et al. The state of immunoreactivity of patients with cervical cancer against the background of extracorporeal immunopharmacotherapy. Bulletin of the National. medical surgeon. center them. N.I. Pirogova. 2018;13(1):98-102. [In Russian].
Kaprin A.D., Starinskiy V.V., Petrova G.V. (Ed.) Sostojanie onkologicheskoj pomoshhi naseleniju Rossii v 2016 godu [The state of cancer care for the population of Russia in 2016]. M.: MNIOI im. P.A. Gercena FGBU «NMIRC» Minzdrava Rossii [M.: MNIOI them. P.A. Herzen FSBI "NMIRC" of the Ministry of Health of Russia], 2017. [in Russian].
Maksimov S.Ya. Pervichno mnozhestvennye opuholi organov reproduktivnoj sistemy [Primarily multiple tumors of the organs of the reproductive system] // Prakticheskaja onkologija [Practical Oncology]. 2009. V.10. N2. P.117-123. [in Russian].
Motuzyuk I., Sydorchuk O., Kovtun N. et al. Analysis of trends and factors in breast multiple primary malignant neoplasms // Breast Cancer (Auckl) 2018. V.12:117822341875995. doi: 10.1177/1178223418759959.
Nyqvist J., Parris T..Z, Helou K. et al. Previously diagnosed multiple primary malignancies in patients with breast carcinoma in Western Sweden between 2007 and 2018. Breast. Cancer. Res. Treat. // 2020. V.184. N1. P.221-228. doi:10.1007/s10549-020-05822-z
Ozan H., Ozerkan K., Aker S. et al. A case with three primary tumors of the ovary, endometrium and gallbladder // Eur. J. Gynaecol. Oncol., 2008. V.29. N5. P.551-553.
Sidorenko Yu.S., Shelyakina T.V., Titova E.V. et al. Problemy pervichno-mnozhestvennyh processov u bol'nyh rakom molochnoj zhelezy [Problems of multiple primary processes in patients with breast cancer] // Sibirskij onkologicheskij zhurnal [Siberian Journal of Oncology], 2010. V.37. N1. P.18-22. [in Russian].
Takatori E., Shoji T., Miura Y. et al. Triple simultaneous primary invasive gynecological malignancies: a case report // J. Obstet. Gynaecol. Res., 2014. V.40. N2. P.627-631. doi:10.1111/jog.12199
Tillyashaikhov M.N., Kamishov S.V. Features of the humoral status of immunity in patients with cervical cancer // International scientific review of the problems and prospects of modern science and education. 2018:84-87
Vogt A., Schmid S., Heinimann K. et al. Multiple primary tumours: challenges and approaches, a review // ESMO Open. 2017. V.2. N2. P.e000172–e000172. doi:10.1136/esmoopen-2017- 000172.
Yuldasheva N.Sh., Navruzova V.S., Akhmedov O.M., Umarova N.A. Kamishov S.V. Features of therapeutic tumor pathomorphosis during X-ray endovascular polychemotherapy in the complex treatment of cervical cancer // Oncology and Radiology of Kazakhstan. -2010;16 (3- 4):96-97 [In Russian]
