CLINICAL AND NEUROLOGICAL CHANGES IN WOMEN DURING LACTATION: SPECIFIC FEATURES AND INFLUENCING FACTORS
Keywords:
lactation, postpartum period, cognitive changes, memory, attention, sleep disturbance, postpartum depression, anxiety, fatigue, breastfeeding, maternal healthAbstract
The lactation period is associated with complex neuroendocrine, metabolic, and psychoemotional adaptations in the female body. During this time, temporary changes in cognitive functions—particularly memory, attention, and executive functioning—may occur, along with sleep disturbances, fatigue, anxiety, and depressive symptoms.In the postpartum period, functional and structural brain changes, sleep fragmentation, nocturnal awakenings, and psychological stress can affect daily functioning, the quality of infant care, and social adaptation.At the same time, breastfeeding may have a protective effect by modulating the stress response and supporting emotional stability. Early identification of cognitive, emotional, and autonomic changes during lactation, along with the assessment of associated risk factors, is important for maintaining maternal health and preventing postpartum complications.
References
Yang, C., et al., Maternal sleep and psychological status in the postpartum period are associated with functional protein alterations in breast milk:a mother-infant cohort study. Clinical Nutrition ESPEN, 2025. 67: p. 510-522.
Horta, B.L., C. Loret de Mola, and C.G. Victora, Long-term consequences of breastfeeding on cholesterol, obesity, systolic blood pressure and type 2 diabetes: a systematic review and meta-analysis. Acta paediatrica, 2015. 104: p. 30-37.
Wallenborn, J.T., et al., Breastfeeding, physical growth, and cognitive development. Pediatrics, 2021. 147(5): p. e2020008029.
Victora, C.G., et al., Breastfeeding in the 21st century: epidemiology, mechanisms, and lifelong effect. The lancet, 2016. 387(10017): p. 475-490.
Masi, A.C. and C.J. Stewart, Role of breastfeeding in disease prevention. Microbial biotechnology, 2024. 17(7): p. e14520.
Cetin, I., et al., International expert consensus on micronutrient supplement use during the early life course. BMC Pregnancy Childbirth, 2025. 25(1): p. 44.
Mezzacappa, E.S., R.M. Kelsey, and E.S. Katkin, Breast feeding, bottle feeding, and maternal autonomic responses to stress. J Psychosom Res, 2005. 58(4): p. 351-65.
Tapırdamaz, Ş.N. and T.Y. Esencan, The Neurological and Psychological Effects of Breastfeeding on Women. The Journal of Neurobehavioral Sciences, 2023. 10(3): p. 68-73.
Fox, M., et al., Women who breastfeed exhibit cognitive benefits after age 50. Evolution, Medicine, and Public Health, 2021. 9(1): p. 322-331.
Shimizu, Y., et al., Reproductive history and risk of cognitive impairment in Japanese women. Maturitas, 2019. 128: p. 22-28.
Harville, E.W., et al., Reproductive history and cognitive aging: the Bogalusa heart study. The American Journal of Geriatric Psychiatry, 2020. 28(2): p. 217-225.
Yoo, J., et al., Female reproductive factors and the risk of dementia: a nationwide cohort study. European journal of neurology, 2020. 27(8): p. 1448-1458.
Pacheco, D., Sleep deprivation and postpartum depression: SleepFoundation. 2022.
Brannon, P.M. and C.L. Taylor, Iron Supplementation during Pregnancy and Infancy: Uncertainties and Implications for Research and Policy. Nutrients, 2017. 9(12).
Peña-Rosas, J.P., et al., Daily oral iron supplementation during pregnancy. Cochrane Database Syst Rev, 2015. 2015(7): p. Cd004736.
Roth, D.E., et al., Global prevalence and disease burden of vitamin D deficiency: a roadmap for action in low- and middle-income countries. Ann N Y Acad Sci, 2018. 1430(1): p. 44-79.
Bollerslev, J., et al., European Expert Consensus on Practical Management of Specific Aspects of Parathyroid Disorders in Adults and in Pregnancy: Recommendations of the ESE Educational Program of Parathyroid Disorders. Eur J Endocrinol, 2022. 186(2): p. R33-r63.