PHARMACORESISTANT EPILEPSY: WAYS TO OVERCOME IT
Keywords:
epilepsy, convulsive syndrome, pharmacoresistance, treatment, antiepileptic drugs.Abstract
Objective: to identify the causes of relative resistance in the treatment of epilepsy with the possibility of eliminating them. Material and Methods: 155 patients with symptomatic epilepsy were examined. Of these, 105 had viral infections (Herpes and CMV) and comorbid with IDA. The average age of the patients was 31.1 ± 2.9 years. Among the surveyed there were 75 (48.4%) men and 80 (51.6%) women. 90 patients showed low treatment efficacy. Results: Correction of the initial therapy by an epileptologist made it possible to increase the efficiency of the optimized therapy by 3.1 times, while the treatment was highly effective, that is, drug remission was achieved in 52.2% (n = 47), which 6.2 times more than the baseline. In 5.5% (n = 5), the optimized therapy was ineffective. Nevertheless, before the optimization of treatment, therapy ineffectiveness was stated 7 times more often (in 38.9%, n = 35). Conclusions: When treating patients with epilepsy, it is necessary to take into account possible diagnostic and therapeutic errors that reduce the effectiveness of treatment, take into account comorbid diseases, as well as conduct explanatory work with the patient and his relatives about the observance of the protective regime and the mandatory adherence to medical and other recommendations of the attending physician.
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