EARLY DIAGNOSTICS OF DISORDERS OF THE NEUROMEDIATOR SYSTEMS WITH THE USE OF NEUROTROPIC AUTOANTIBODIES IN PERSONS WITH COVID-19
Keywords:
COVID-19, nervous system, neurotropic autoantibodies, early diagnosisAbstract
COVID-19 is a new disease in the history of mankind, but the neurotropic properties of the causative agent of this disease SARS-CoV-2 are already beyond doubt. It is well known that some neurotropic viruses can cause nervous system disease several years after infection, and perhaps this also applies to coronavirus infection. Given the pandemic situation, this could have serious consequences in the form of an increase in the number of patients with neurological disorders in the future. The method of immunochemical analysis ELI-Neuro-Test, developed by Professor A.B. Poletaev, makes it possible to comprehensively assess the state of neurotransmitter systems and, long before the appearance of neurological symptoms, with a high probability of predicting diseases of the central nervous system, in particular those associated with COVID-19. Using this method, an individual profile of serum immunoreactivity is analyzed, depending on changes in the relative content of IgG autoantibodies directed to 12 autogens of the nervous system. In our small study, we identified in patients who underwent COVID-19 immunochemical signs of damage to the GABAergic (58.6%), opioid (37.9%), serotonergic (20.7%), cholinergic (13.8%) neurotransmitter systems, and also markers of axonal damage (20.7%), demyelination (10.3%) and reactive astrogliosis (24.1%), which suggest what variety of neurological deficits can be expected in the medium and long-term in patients with SARS-CoV-2 infection.
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