ASSESSMENT OF DENTAL STATUS AND THE ROLE OF CHRONIC PANCREATITIS AS A RISK FACTOR FOR PERIODONTAL DISEASES

Authors

  • Yusupalikhodjaeva Saodat Khamidullaevna
  • Muqimova Hurriyat Olimjon qizi

Keywords:

chronic pancreatitis, chronic periodontitis, risk factor, correlation of indicators

Abstract

Chronic pancreatitis (CP) as a systemic disease can affect the condition of the oral cavity, including the development of periodontal diseases. The article presents an assessment of the dental status of patients with CP using clinical indices (OHIS, SBI, PI, PMA, periodontal pocket depth) and analyzes the role of CP as a risk factor for periodontal pathologies. The results showed a significant deterioration in oral hygiene, increased gingival bleeding and periodontitis progression in this group of patients. Correlation analysis revealed moderate and strong relationships between hygiene indicators and periodontal condition (r = 0.53–0.75), as well as an unexpected negative correlation with PMA (r = -0.56). It has been established that the systemic effects of CP, including inflammation and metabolic disorders, increase the risk of periodontitis. The data obtained emphasize the need for a comprehensive approach to the management of such patients and open up prospects for further research into the mechanisms of this relationship.

References

Бордин Д.С., Винокурова Л.В., Дубцова Е.А. и др. Качество жизни больных хроническим панкреатитом с функциональной недостаточностью поджелудочной железы. Доктор.Ру. 2014;91(3):54–9.

Васильева, Н. А. Стоматологический статус больных с заболеваниями пародонта / Н. А. Васильева, А. И. Булгакова, Е. С. Солдатова // Медицинский вестник Башкортостана. - 2016. - Т. 11, № 6 (66). - С. 31-35.

Ивашкин В.Т., Маев И.В., Охлобыстин А.В. и др. Рекомендации Российской гастроэнтерологической ассоциации по диагности-ке и лечению хронического панкреатита. РЖГГК. 2014;4:70–97.

Кучерявый Ю.А. Особенности микронутриентного статуса пациентов с хроническим панкреатитом. Фарматека. №2 (295) / 2015 - Гастроэнтерология / Гепатология. С.31-38.

Наврузова Ф. Р., Юсупалиходжаева С. Х. Социально-демографическая характеристика пациентов страдающих кандидозом слизистой оболочки полости рта //5th International Conferenceon Innovations and Development Patterns in Technical and Natural Sciences. – 2018. – С. 29-32.

Юсупалиходжаева С. Х., Бекжанова О. Е., Патхиддинов Ж. Ш. ЭТИОЛОГИЧЕСКИЕ ФАКТОРЫ РАЗВИТИЯ КАНДИДОЗА СЛИЗИСТОЙ ОБОЛОЧКИ ПОЛОСТИ РТА //Стоматология-наука и практика, перспективы развития. – 2018. – С. 362-363.

Abdellatif H., Binshabaib M., Shawky H., Alharthi S. Association between Periodontitis and Genetic Polymorphisms in Interleukins among Patients with Diabetes Mellitus. Dent. J. 2021;9:45. doi: 10.3390/dj9040045

Arimatsu K et al. Oral pathobiont induces systemic inflammation and metabolic changes associated with alteration of gut microbiota. Scientific reports. 4, 4828 (2014).

Beyer G, Habtezion A, Werner J, Lerch MM, Mayerle J. Chronic pancreatitis.Lancet 2020;396:499-512.

Bogdan M., Tica I., Gheorghe D.N., Siloşi I., Solomon S.M., Martu I., Surlin P., Chiscop I., Budacu C.C. Effect of 0.2% Chlorhexidine’ s Use for Treatment of Localized Gingival Lesions in Patients with Type 2 Diabetes. Rev. Chim. 2017;67:2651–2653.

Bui F. Q. et al. Association between periodontal pathogens and systemic disease //Biomedical journal. – 2019. – Т. 42. – №. 1. – С. 27-35.

Cao P et al. Fusobacterium nucleatum Activates Endoplasmic Reticulum Stress to Promote Crohn’s Disease Development via the Upregulation of CARD3 Expression. Front Pharmacol. 11, 106 (2020).

Chen Y, Chen Y, Cao P, Su W, Zhan N, Dong W Fusobacterium nucleatum facilitates ulcerative colitis through activating IL‐17F signaling to NF‐κB via the upregulation of CARD3 expression. The Journal of Pathology. 250, 170–182 (2020).

Hegyi P, Párniczky A, Lerch MM, et al. International Consensus Guidelines for Risk Factors in Chronic Pancreatitis. Recommendations from the working group for the international consensus guidelines for chronic pancreatitis in collaboration with the International Association of Pancreatology, the American Pancreatic Association, the Japan Pancreas Society, and European Pancreatic Club. Pancreatology 2020;20:579-585.

Kato T et al. Oral Administration of Porphyromonas gingivalis Alters the Gut Microbiome and Serum Metabolome. mSphere. 3, (2018).

Martínez-García M., Hernández-Lemus E. Periodontal Inflammation and Systemic Diseases: An Overview. Front. Physiol. 2021;12:709438. doi: 10.3389/fphys.2021.709438.

Miskiewicz A, Szparecki G, Durlik M, Rydzewska G, Ziobrowski I, Górska R. The correlation between pancreatic dysfunction markers and selected indices of periodontitis. Adv Clin Exp Med. 2018 Mar;27(3):313-319. doi: 10.17219/acem/64937. PMID: 29558037.

Sanz M., Ceriello A., Buysschaert M., Chapple I., Demmer R., Graziani F., Herrera D., Jepsen S., Lione L., Madianos P., et al. Scientific evidence on the links between periodontal diseases and diabetes: Consensus report and guidelines of the joint workshop on periodontal diseases and diabetes by the International Diabetes Federation and the European Federation of Periodontology. J. Clin. Periodontol. 2017;45:138–149. doi: 10.1111/jcpe.12808.

Singh VK, Yadav D, Garg PK. Diagnosis and management of chronic pancreatitis: a review. JAMA 2019;322:2422-2434.

Vege SS, Chari ST. Хронический панкреатит. N Engl J Med. 2022 Mar 3;386(9):869-878. doi: 10.1056/NEJMcp1809396. PMID: 35235728.

Yamazaki K et al. Oral Pathobiont-Induced Changes in Gut Microbiota Aggravate the Pathology of Nonalcoholic Fatty Liver Disease in Mice. Frontiers in Immunology. 12, (2021).

Yusupalikhodjaeva S. H. et al. Factors for persistence of candida albicans, defined in patients with oral moniliasis of oral cavity //European Science Review. – 2018. – №. 7-8. – С. 187-190.

Yusupalikhodjaeva S. K., Davurov A. M., Qosimova G. I. Nosological forms of candidal stomatitis occurring in patients with diseases of the oral mucosa //5th International Conferenceon Innovations and Development Patterns in Technical and Natural Sciences. – 2018. – С. 47-50.

Published

2025-08-30