MODERN STRATEGIES FOR THE PREVENTION AND TREATMENT OF ODONTOGENIC INFLAMMATORY LESIONS OF JAW BONE TISSUE: RATIONALE FOR INTERDISCIPLINARY INTERACTION
Keywords:
Odontogenic osteitis, jaw osteomyelitis, prevention, treatment, antibacterial therapy, surgical treatment, microbiological diagnosticsAbstract
Odontogenic inflammatory lesions of jaw bone tissue represent one of the most complex problems in modern maxillofacial surgery and dentistry. According to domestic and foreign researchers, the incidence of odontogenic osteomyelitis ranges from 2.3% to 18.7% among all inflammatory diseases of the maxillofacial region, with a trend towards an increase in severe and complicated cases. The etiopathogenesis of odontogenic inflammatory lesions of jaw bone tissue is characterized by multiple factors, including local and general risk factors. Local factors include carious lesions, pulpitis, periodontitis, traumatic dental interventions, and disturbances in local blood circulation and immunity. General factors include immunodeficiency conditions, endocrine disorders, systemic connective tissue diseases, oncological diseases, and their treatment.
References
Andreev I.M., Petrosyan G.G., Stepanov A.V. et al. Comprehensive microbiome analysis in odontogenic osteomyelitis of the jaws: new possibilities of personalized therapy. Dentistry. 2022;101 (4):23-31.
Belyakov N.A., Sokolova M.V., Ivanov S.Yu. et al. Clinical assessment of patients with odontogenic osteitis: recommendations of the 2023 expert consensus. Journal of Infectious Pathology. 2023. 30 (2): 89-105.
Volkov A.G., Dmitriev N.S., Korablin M.M. et al. Hereditary factors of predisposition to odontogenic osteomyelitis: analysis of pologenome associations. Medical Genetics. 2021; 20 (6): 15-28.
Grigoriev S.S., Markov P.V., Aleksandrov I.O. et al. Immunological and cytokine profiles in odontogenic osteitis: systematic review and meta-analysis. Immunology and Allergology. 2023. 42 (3): 234-251.
Martinov D.V., Gantsev K.Sh., Printsev A.A. Odontogenic osteomyelitis of the jaws: clinical spectrum and modern approaches to treatment. Maxillofacial Surgery. 2021; 15 (2):45-67.
Morozov I.A., Brennan E.M., Djonko S. et al. Treatment of acute odontogenic ostitis in a large population sample. Journal of Maxillofacial Surgery. 2022, p. 34 (3): 156-173.
Pashkov E.P., Fernandes T.V., Sharp F. et al. Genetic architecture of odontogenic osteomyelitis: the role of rare and frequent variants in the disruption of the immune response and bone metabolism. Molecular Medicine. 2021;28:154-169.
Robertson M.M., Yeapen V., Singer H.S. et al. Odontogenic remains of the maxillofacial region: modern concepts. Reviews on Dentistry. 2020; 3:78-94.
