HEMOSTATIC SYSTEM STATUS IN PATIENTS WITH PERIODONTITIS ASSOCIATED WITH STABLE ANGINA PECTORIS
Keywords:
chronic generalized periodontitis, stable angina pectoris, hemostasis, platelets, endothelial dysfunction, von Willebrand factor, antithrombin III, protein C, hypercoagulation, thrombosis, microcirculationAbstract
The article presents the results of a study on the state of the hemostatic system in patients with chronic generalized periodontitis (CGP) associated with stable angina pectoris. A total of 60 patients aged 45–60 years were examined. The findings revealed significant hemostatic alterations in this group, including thrombocytopenia, increased platelet aggregation, prolonged recalcification time after calcium reintroduction, decreased levels of antithrombin III and protein C, along with elevated von Willebrand factor activity. These changes indicate endothelial dysfunction and a narrow range of hemostatic balance maintenance, which increase the risk of both thrombotic and hemorrhagic complications. Timely identification of such hemostatic disorders is essential for preventing complications and improving patients’ quality of life.
References
Кондюрова Е.В., Власова Т.И., Трофимов В.А., Власов А.П., Адамчик Р.А., Акимов В.В., Ташина Е.А.Состояние тромбоцитарного звена системы гемостаза в патогенезе прогрессирования хронического пародонтита //Российский медико-биологический вестник им. акад. И.П. Павлова. -2019. -Т.27, № 2. –С.209–218.
Пименова М.П., Арутюнов С.Д.Особенности течения хронических воспалительных заболеваний тканей пародонта у больных острым инфарктом миокарда //Российский стоматологический журнал. -2014. - №4. –С.78-82.
Трухан Д. И. и соавт.Пародонтит и сердечно-сосудистые заболевания: параллельно или в одной связке? //ConsiliumMedicum. dental-press.ru+4consilium.orscience.ru+4Acta Naturae+4
Усманова Ш.И., Хожиметов А.А.Состояние системы гемостаза при хроническом генерализованном пародонтите у лиц с хронической ишемией мозга //Медицинский журнал. -2016. -Т. 21, №4. –С.44–46.
Allison, M. G., Shanholtz, C. B., Sashdeva, A. Prothrombotic state in patients with sepsis and the role of antithrombotic therapies. // Current Infectious Disease Reports. – 2016. – Vol. 18, No. 6. – P. 1–9.
Marfil-Alvarez R. Acute Myocardial Infarct Size Is Related to Periodontitis Extent and Severity //Journal of Dental Research, -2014. –Р.102-106.
Rustamova S. M. et al. Correlation relations of the composition of saliva and blood plasma in the norm //British View. – 2022. – Т. 7. – №. 4.
