POLYMORPHIC GENES OF THE FOLATE CYCLE AND CONGENITAL MALFORMATIONS OF THE MAXILLOFACIAL REGION
Keywords:
malformations of the maxillary region, cleft lip, cleft palate, folate cycle genes, MTHFR (C677T), MTHFR (A1298C), MTR (A2756G), MTRR A66G (Ile22Met)Abstract
The analysis of the results of studies on the assessment of the contribution of polymorphic loci of the folate cycle genes to the mechanisms of HPLC formation indicates that the genetic component is quite complex, in which the specific role of any one gene is very small, and their development is more likely the result of the interaction of polymorphic variants of several genes in combinations with the influence of exogenous factors. In this connection, further study of molecular genetic mechanisms, the search for molecular genetic determinants that contribute to the formation of congenital malformations of the maxillofacial region among the Uzbek population seems to be very interesting and relevant.
References
Abdollahi-fakhim S, Estiar MA, Varghaei P. Common Mutations of the Methylenetetrahydrofolate Reductase (MTHFR) Gene in Non-Syndromic Cleft Lips and Palates Children in North-West of Iran. 2015;27(78):7-14.
Amooee, A., Dastgheib, S. A., Niktabar, S. M., Noorishadkam, M., Lookzadeh, M. H., Mirjalili, S. R., … Neamatzadeh, H. (2019). Association of Fetal MTHFR 677C > T Polymorphism with Non-Syndromic Cleft Lip with or without Palate Risk: A Systematic Review and Meta-Analysis. Fetal and Pediatric Pathology, 1–17. doi:10.1080/15513815.2019.1707918.
Bezerra, J., Oliveira, G., Soares, C., Cardoso, M., Ururahy, M., Neto, F., … Hirata, M. (2014). Genetic and non-genetic factors that increase the risk of non-syndromic cleft lip and/or palate development. Oral Diseases, 21(3), 393–399. doi:10.1111/odi.12292.
Butali A, Little J, Chevrier C, Cordier S, Steegers-Theunissen R, Jugessur A, Oladugba B, Mossey PA. Folic acid supplementation use and the MTHFR C677T polymorphism in orofacial clefts etiology: an individual participant data pooled-analysis. Birth Defects Res A Clin Mol Teratol 2013;97:509–14.
Buzrukzoda J.D., Kubaev A.S., Abdullaev A.S. Elimination Of Perforation Of The Bottom Of The Maxilla Jaw Sinus With Application Of Osteoplastic Material //CENTRAL ASIAN JOURNAL OF MEDICAL AND NATURAL SCIENCES. – 2021. – Т. 2. – №. 1. – С. 162-166.
Colson NJ, Naug HL, Nikbakht E, Zhang P, McCormack J. The impact of MTHFR 677C/T genotypes on folate status markers: a metaanalysis of folic acid intervention studies. Eur J Nutr 2017;56:247–60.
Deniz Aşlar, Hakkı Taştan. Prevalence of MTHFR, MTR and MTRR Gene Polymorphisms in Turkish Patients with Nonsyndromic Cleft Lip and Palate. Gene Ther Mol Biol Vol 16, 115-129, 2014.
Han Y, Pan Y, Du Y, Tong N, Wang M, Zhang Z, Wan L, Wang L. 2011. Methylenetetrahydrofolate reductase C677T and A1298C polymorphisms and nonsyndromic orofacial clefts susceptibility in a southern Chinese population. DNA Cell Biol 30:1063–1068.
Imani, M.M., Golchin, N., Safaei, M. et al. Methylenetetrahydrofolate reductase C677T polymorphism is not associated with the risk of nonsyndromic cleft lip/palate: An updated meta-analysis. Sci Rep 10, 1531 (2020). https://doi.org/10.1038/s41598-020-58357-0.
Jiang, C., Yin, N., Zhao, Z., Wu, D., Wang, Y., Li, H., & Song, T. (2015). Lack of Association between MTHFR, MTR, MTRR, and TCN2 Genes and Nonsyndromic CL±P in a Chinese Population: Case-Control Study and Meta-Analysis. The Cleft Palate-Craniofacial Journal, 52(5), 579–587. doi:10.1597/14.067.
Khazratov AI, Rizaev JA, Lisnychuk NY, Reimnazarova GD, Kubaev AS, Olimjonov KJ. Morphofunctional Characteristics Of The Oral Mucosa Of Experimental Rats In Experimental Carcinogenesis. European Journal of Molecular and Clinical Medicine. 2021 Jan 15;8(2):227-35.
Komiyama Y. et al. 5, 10‑Methylenetetrahydrofolate reductase (MTHFR) C677T/A1298C polymorphisms in patients with nonsyndromic cleft lip and palate //Biomedical Reports. – 2020. – Т. 13. – №. 6. – С. 1-1.
Krost B, Schubert J. Influence of season on prevalence of cleft lip and palate // International Journal of Oral and Maxillofacial Surgery. – 2006. –Vol. 35 – №3. – P. 215–218.
Kubaev AS. PATIENTS ASSOCIATED INJURIES WITH FRACTURES OF THE MAXILLOFACIAL REGION: 118 PATIENTS REVIEW. Достижения науки и образования. 2022(1 (81)):90-4.
Lei, W., Xia, Y., Wu, Y., Fu, G., & Ren, A. (2018). Associations Between MTR A2756G, MTRR A66G, and TCN2 C776G Polymorphisms and Risk of Nonsyndromic Cleft Lip with or Without Cleft Palate: A Meta-Analysis. Genetic Testing and Molecular Biomarkers, 22(8), 465–473. doi:10.1089/gtmb.2018.0037.
Murthy, J., Gurramkonda, V. B., & Lakkakula, B. V. K. S. (2015). Genetic variant in MTRR A66G, but not MTR A2756G, is associated with risk of non-syndromic cleft lip and palate in Indian population. Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology, 27(6), 782–785. doi:10.1016/j.ajoms.2015.04.008.
Pan Y, Zhang W, Ma J, Du Y, Li D, Cai Q, Jiang H, Wang M, Zhang Z, Wang L. Infants’ MTHFR polymorphisms and nonsyndromic orofacial clefts susceptibility: a meta-analysis based on 17 case–control studies. Am J Med Genet A 2012;158A:2162–9.
Rizaev Elyor Alimdjanovich, & Buzrukzoda Javokhirkhon Davron. (2023). HEALING WITH THE USE OF TITANIUM THREADS OF CONTROLLED BONE RESORPTION. American Journal of Interdisciplinary Research and Development, 16, 9–14. Retrieved from http://ajird.journalspark.org/index.php/ajird/article/view/649
Rizaev, E. A., & Buzrukzoda, J. D. (2022). OPTIMIZATION OF GUIDED BONE REGENERATION IN CONDITIONS OF JAW BONE ATROPHY. Applied Information Aspects of Medicine (Prikladnye informacionnye aspekty mediciny), 25(4), 4-8.
Rozendaal AM, van Essen AJ, te Meerman GJ, Bakker MK, van der Biezen JJ, Goorhuis-Brouwer SM, Vermeij-Keers C, de Walle HE. Periconceptional folic acid associated with an increased risk of oral clefts relative to non-folate related malformations in the Northern Netherlands: a population-based case–control study. Eur J Epidemiol 2013; 28:875–87.
Stuppia L., Capogreco M., Marzo G., Rovere D.L., Antonucci I, et al. Genetics of Syndromic and Nonsyndromic Cleft Lip and Palate. J Craniofac Surg. 2011;2(5):1722-1726.
Ризаев Ж., Кубаев А., Бузрукзода Ж. Современный подход к комплексной реабилитации пациентов с приобретенными дефектами верхней челюсти (обзор литературы) //Журнал стоматологии и краниофациальных исследований. – 2021. – Т. 2. – №. 3. – С. 77-83.
