ЯЗВЕННАЯ БОЛЕЗНЬ ЖЕЛУДКА И ДВЕНАДЦАТИПЕРСТНОЙ КИШКИ, АССОЦИИРОВАННАЯ С HELICOBACTER PYLORI, И ДЕФИЦИТ ВИТАМИНА D: ПРОБЛЕМА В ИНТЕРПРЕТАЦИИ ЛИТЕРАТУРЫ
Ключевые слова:
Helicobacter pylori, витамин D, 25(OH)D, полиморфизм VDR, кателицидин, β-дефензин, эрадикация, антимикробные пептиды, мукозальный иммунитет, язвенная болезнь, клиническое течение, УзбекистанАннотация
В данной научной статье анализируется клиническое течение язвенной болезни желудка и двенадцатиперстной кишки, ассоциированной с Helicobacter pylori, на фоне дефицита витамина D. Результаты исследований показали, что у пациентов с низким уровнем 25(OH)D в сыворотке крови риск неэффективности эрадикационной терапии значительно выше. Помимо этого, установлено, что полиморфизмы гена VDR — FokI, BsmI, ApaI и TaqI — могут влиять на восприимчивость к инфекции Helicobacter pylori, особенности течения воспалительного процесса и результаты лечения. В данной статье комплексно освещены роль дефицита витамина D в патогенезе Helicobacter pylori, его влияние на клинические проявления гастродуоденальной язвенной болезни, а также современные подходы к эрадикационной терапии на основе отечественных и зарубежных научных источников.
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