OG‘RIQSIZLANTIRISH TA’SIRIDA YO‘G‘ON ICHAKDA YUZAGA KELGAN TAJRIBADAN KEYINGI GISTOLOGIK O‘ZGARISHLAR
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Og‘riqsizlantirish, uchuvchi anestetiklar##article.abstract##
Ushbu ilmiy ishda tajriba modeli asosida turli og‘riqsizlantirish vositalari qo‘llanilgach, yo‘g‘on ichakda sodir bo‘ladigan morfologik o‘zgarishlar o‘rganildi. Garchi og‘riqsizlantiruvchi preparatlar amaliyotlarda keng qo‘llansa-da, ularning ichak tuzilmasiga bo‘lgan ta’siri hali yetarlicha o‘rganilmagan. Shu maqsadda 48 ta laboratoriya kalamushlari ishtirokida nazoratli tajriba o‘tkazildi. Unda klinik sharoitda keng ishlatiladigan izofluran, sevofluran va propofol preparatlari muayyan dozada yuborilib, ularning yo‘g‘on ichak to‘qimalarida yuzaga keltirgan gistopatologik o‘zgarishlari tahlil qilindi. To‘qimalar aniq belgilangan vaqtlarda – 3, 6, 12 va 24 soatdan so‘ng yig‘ildi va batafsil mikroskopik tekshiruvdan o‘tkazildi. Ushbu natijalar operatsiyadan so‘nggi ichak faoliyatining buzilish mexanizmlarini yanada chuqurroq tushunishga yordam beradi. Tadqiqot shuni ko‘rsatadiki, jarrohlik amaliyotlarida, ayniqsa ichak butunligi muhim bo‘lgan holatlarda og‘riqsizlantirish vositasining turi va uning davomiyligi diqqat bilan tanlanishi zarur. Ushbu tahlillar gastrointestinal asoratlarning oldini olishga va klinik amaliyotda og‘riqsizlantiruvchi tanlashda asosli yondashuvni shakllantirishga xizmat qiladi.
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