ALLOKSANLI QANDLI DIABET NEGIZIDA JIGAR ABSSESSLARI DAVOLASH NATIJALARINI BAHOLASH BO‘YICHA EKSPERIMENTAL TADQIQOTLAR
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jigar abssessi; eksperimental tadqiqotlat; alloksanli qandli diabet; dioksidin; levofloksatsin##article.abstract##
Jigarning o‘tkir yiringli abssessini modellashtirishda eksperimental tadqiqotlar o‘tkazish uchun boshlang‘ich printsip sifatida ko‘richak najas mikroflorasi bilan 10 mg miqdorida singdirilgan, 1,0 ml fiziologik eritmada suyultirilgan, 7 mm diametrli doka sharidan foydalangan holda, u tirik loblar orasiga o‘rnatildi.. Implantatsiyadan keyingi kun intoksikatsiya, sepsis va jigarda destruktiv cheklangan fokusning shakllanishining odatiy rasmi kuzatildi. Implantatsiyadan keyingi kun infektsiya manbai abssess bo‘shlig‘ini 2% dioksidin eritmasi va 0,5 ml levofloksatsinning 10% eritmasini abssess bo‘shlig‘iga kiritish orqali olib tashlandi. Hayvonlarning eksperimental guruhida levoflotsiklin eritmasi kiritilgandan so‘ng, NEL nurlanishi to‘lqin uzunligi 337 nm, quvvati 5,0 mVt va davomiyligi 1 minut bilan amalga oshirildi. Hayvonlarning nazorat guruhida shifo dinamikasi asta-sekin davom etdi, detrit va fibrin birikmalari bilan xo‘ppoz bo‘shlig‘i operatsiyadan keyingi 45-kuni saqlanib qoldi, garchi hayvonlarning umumiy holati 14-21 kunlarda allaqachon normallashgan bo‘lsada. Hayvonlarning eksperimental guruhida tiklanish tezroq sodir bo‘ldi. Shunday qilib, 3-kuni hayvonlar qafas atrofida faol harakat qilishdi; Jismoniy faollikni tiklash operatsiyadan keyingi 7-kuni sodir bo‘ldi. Abssess bo‘shlig‘i tezroq yopildi. 7-kunga kelib, abssess bo‘shlig‘i detritdan tozalandi. Destruktsiya markazining hajmi kamaydi. Jarrohlikdan keyin fibrin qoplamalari 14 kun davomida saqlanib qoldi. Abssess bo‘shlig‘ini tozalash va davolash operatsiyadan 21 kun o‘tgach sodir bo‘ldi.
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