ENDOCRINE LUNG STRUCTURES IN ONTOGENESIS IN CHILDREN WITH PNEUMONIA
Keywords:
ontogenesis, children, pneumonia, apudocytes, hyperplasia, histologyAbstract
During human embryonic lung histogenesis, early morphofunctional differentiation of apudocytes is observed. In young children with inflammatory pathology of this organ, endocrine structures are detected with great consistency in the lungs, and the number is large. The longer the disease lasts, the more apudocytes and NET are detected in the bronchi and respiratory departments. There are more endocrine structures in large bronchi than in small ones. Inflammatory lung diseases in early postnatal ontogenesis are a predisposing factor for apudocyte hyperplasia.
References
Young LR, Brody AS, Inge TH, Acton JD, Bokulic RE, Langston C, Deutsch GH.
Neuroendocrine cell distribution and frequency distinguish neuroendocrine cell hyperplasia of infancy from other pulmonary disorders. Chest. 2011. 139(5): 1060-71.
Koo CW, Baliff JP, Torigian DA, Litzky LA, Gefter WB, Akers SR.Spectrum of pulmonary neuroendocrine cell proliferation: diffuse idiopathic pulmonary neuroendocrine cell hyperplasia, tumorlet, and carcinoids. Am J Roentgenol. 2010 Sep;195(3):661-8.
Linnoila RI. Functional facets of the pulmonary neuroendocrine system. Laboratory Investigation .2006. 86, 425–444
Rizvi SM, Goodwill J, Lim E, Yap YK, Wells AU, Hansell DM, Davis P, Selim AG, Goldstraw P, Nicholson AG. The frequency of neuroendocrine cell hyperplasia in patients with pulmonary neuroendocrine tumours and non-neuroendocrine cell carcinomas. Histopathology. 2009.55(3):332-7.
Susan J Davies, John R Gosney, David M Hansell, Athol U Wells, Roland M du Bois, Margaret M Burke, Mary N Sheppard, and Andrew G Nicholson. Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia: an under‐recognised spectrum of disease. Thorax. 2007; 62(3): 248–252.
Swarts DR, Ramaekers FC, Speel EJ. Molecular and cellular biology of neuroendocrine lung tumors: evidence for separate biological entities. Biochim Biophys Acta. 1826(2):255-71.
