PRECACHEXIA BIOMARKERS IN WOMEN WITH REPRODUCTIVE SYSTEM CANCER: A COMPREHENSIVE DIAGNOSTIC APPROACH
Keywords:
precachexia, oncology, biomarkers, interleukin-6, nutritional statusAbstract
Objective: To develop and validate a diagnostic panel of biomarkers for early detection of precachexia in cancer patients. Materials and Methods: A prospective cohort study was conducted involving 197 patients, divided into three groups based on nutritional status: normal (n=64), precachexia (n=81), and cachexia (n=52). ROC analysis, internal consistency assessment (Cronbach's α), test-retest analysis, and correlation study methods were used. Biomarkers included C-reactive protein, interleukin-6, tumor necrosis factor-α, and albumin. Results: A statistically significant increase in inflammatory markers was found with the progression of nutritional deficiency. Interleukin-6 demonstrated the highest diagnostic value (area under the ROC curve 0.899). A combined model was developed with 91.1% sensitivity and 92.4% specificity, superior to individual biomarkers. Conclusions: A comprehensive approach to assessing inflammation and protein metabolism biomarkers significantly improves the accuracy of early precachexia diagnosis in cancer patients. The proposed diagnostic model can be recommended for clinical use to timely identify nutritional disorders.
References
Султонова, Л. Ж., Халикова, Ф. Ш., Мамедов, У. С., & Баратова, Ш. Б. (2022). Диагностика и лечение рецидивов рака молочной железы. Oriental renaissance: Innovative, educational, natural and social sciences, 2(5-2), 128-146.
Argilés J.M., Stemmler B., López-Soriano F.J. et al. Inter-tissue communication in cancer cachexia // Nat Rev Endocrinol. 2019. Vol. 15. P. 9-20
Kumar N.B., Kazi A., Smith T. et al. Cancer cachexia: traditional therapies and novel molecular mechanism-based approaches to treatment // Curr Treat Options Oncol. 2021. Vol. 22. P. 88
Maxmudova, G. F., Soxibova, Z. R., Mamedov, U. S., & Nurboboyev, A. U. (2021). FERTIL VA KEKSA YOSHLI AYOLLARDA BACHADON BO ‘YNI XAVFLI O ‘SMALARI TAHLILI (BUXORO VILOYATIDA). Oriental Renaissance: Innovative, educatinal, natural and social sciences, 1(8), 175-184.
Shavkatovna S. S., Makhammatkulovich R. N., Ugli M. S. T. ASPECTS OF SARCOPENIA SYNDROME IN ONCOLOGICAL PRACTICE: DIAGNOSIS AND TREATMENT //The American Journal of Medical Sciences and Pharmaceutical Research. – 2024. – Т. 6. – №. 02. – С. 16-25.
Shakhanova S. S., Rakhimov N. M. The role of troponin and IL-6 in immunological assessment of sarcopenia in oncological patients //Central Asian Journal of Medical and Natural Science. – 2025. – Т. 6. – №. 3. – С. 1229-1233.
