MARKERS OF INFLAMMATION IN BRONCHIAL ASTHMA IN CHILDREN WITH CONSEQUENCES OF PERINATAL LESION TO THE CENTRAL NERVOUS SYSTEM
Keywords:
bronchial asthma, children, inflammatory markers, central nervous system, perinatal damageAbstract
Aim: to study the features of the course of bronchial asthma in children with perinatal damage to the central nervous system.
Materials and methods: The study is based on data from a comprehensive examination of 90 children, divided into two groups, comparable by gender and age. There 53 children aged 5 to 11 years with BA due to the consequences of perinatal central nervous system damage made up the main group. The comparison group consisted of 37 children aged 6 to 11 years with asthma without concomitant neurological symptoms.
Results: The studies conducted showed that in the sick children with asthma we examined against the background of the consequences of perinatal damage to the CNS, pronounced changes in intercellular immune mechanisms were observed. The revealed direction of immune changes and their severity indicate the important pathogenetic role of immune mechanisms in the development and progression of changes in the state of the immune system in children with BA with concomitant damage to the CNS of functional origin.
Conclusions: It was found that children in the main group had lower indicators of physical activity and PEF in relation to the indicators of children in the comparison group. A comparative analysis of the cytokine status of children with BA against the background of the consequences of perinatal damage to the central nervous system with data from children with asthma without concomitant neurological symptoms showed a significant imbalance and significantly high levels of IL-6, IL-8 and TNF-α in the main group of patients.
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Статья поступила в редакцию 05.01.2024; одобрена после рецензирования 18.02.2024; принята к публикации 20.02.2024.
The article was submitted 05.01.2024; approved after reviewing 18.02.2024; accepted for publication 20.02.2024.
Информация об авторах:
Хайдарова Сарвиноз Хайдаржоновна – докторант кафедры пропедевтики детских болезней, PhD. Самаркандский государственный медицинский университет, Самарканд, Узбекистан. E-mail: sarvinozx88@mail.ru, https://orcid.org/ 0000-0002-2840-6016
Мавлянова Зилола Фархадовна - д.м.н., доцент, заведующая кафедрой медицинской реабилитации, спортивной медицины и народной медицины. Самаркандский государственный медицинский университет, Самарканд, Узбекистан. Е-mail: reab.sammi@mail.ru, https://orcid.org/ 0000-0001-7862-2625
Источники финансирования: Работа не имела специального финансирования.
Конфликт интересов: Авторы декларируют отсутствие явных и потенциальных конфликтов интересов, связанных с публикацией настоящей статьи.
Вклад авторов:
Хайдарова С.Х. - сбор и анализ источников литературы, написание текста
Мавлянова З.Ф. - идеологическая концепция работы, редактирование текста
Information about the authors:
Khaidarоva Kh. Sarvinoz - Doctoral student of the Department of Propaedeutics of Childhood Diseases, PhD. Samarkand state medical university. Samarkand, Uzbekistan; E-mail: sarvinozx88@mail.ru, https://orcid.org/ 0000-0002-2840-6016
Mavlyanova F. Zilola - DSc, associate professor, Head of the department of medical rehabilitation, sports medicine and folk medicine. Samarkand state medical university. Samarkand, Uzbekistan; E-mail: reab.sammi@mail.ru, https://orcid.org/ 0000-0001-7862-2625
Sources of funding: The work did not receive any specific funding.
Conflict of interest: The authors declare no explicit or potential conflicts of interest associated with the publication of this article.
Contribution of the authors:
Khaidarova S.Kh. - collection and analysis of literature sources, writing the text
Mavlyanova Z.F. - ideological concept of the work, editing the article
