MARKAZIY ASAB TIZIMINING PERINATAL SHIKASTLANISHI OQIBATLARI BO'LGAN BOLALARDA BRONXIAL ASTMA YALLIG'LANISH MARKERLARI
##article.subject##:
bronxial astma, bolalar, yallig'lanish belgilari, мarkaziy asab tizimi, perinatal shikastlanish##article.abstract##
Tadqiqot maqsadi: markaziy asab tizimiga perinatal shikastlanish bilan bolalarda bronxial astma kechishining xususiyatlarini o'rganish.
Materiallar va usullar: tadqiqot jinsi va yoshi bo'yicha teng taqqoslanadigan ikki guruhga bo'lingan 90 nafar bolani har tomonlama tekshirish ma'lumotlariga asoslanadi. Shulardan markaziy asab tizimining perinatal shikastlanishi oqibatlari tufayli bronxial astma bilan kasallangan 5 yoshdan 11 yoshgacha bo'lgan 53 nafar bola asosiy guruhni tashkil etdi. Taqqoslash guruhi 6 yoshdan 11 yoshgacha bo'lgan astma bilan og'rigan, nevrologik o'zgarishlarsiz 37 nafar boladan iborat edi.
Natijalar: bizning tadqiqotlarimiz shuni ko'rsatdiki, astma bilan kasallangan bolalarda biz markaziy asab tizimining perinatal shikastlanishi oqibatlari fonida tekshirilganda hujayralararo immunitet mexanizmlarida yaqqol o'zgarishlar kuzatilgan. Immunitet o'zgarishlarining aniqlangan yo'nalishi va ularning namoyon bo'lishi bir vaqtning o'zida markaziy asab tizimiga zarar yetkazadigan BA bilan bolalarda immunitet tizimining holatidagi o'zgarishlarning rivojlanishida immun mexanizmlarining muhim patogenetik rolini ko'rsatadi.
Xulosa: Taqqoslash guruhidagi bolalarning ko'rsatkichlariga nisbatan asosiy guruhdagi bolalarda TNF va NChPT ko'rsatkichlari pastroq ekanligi aniqlandi.Markaziy asab tizimining perinatal shikastlanishi oqibatlari fonida BA bilan bolalarning sitokin holatini nevrologik belgilari bo'lmagan BA bilan bolalarning ma'lumotlari bilan qiyosiy tahlil qilish sezilarli nomutanosiblik va bemorlarning asosiy guruhida IL-6, IL-8 va TNF-a ning sezilarli darajada yuqori miqdorini ko'rsatdi.
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Статья поступила в редакцию 05.01.2024; одобрена после рецензирования 18.02.2024; принята к публикации 20.02.2024.
The article was submitted 05.01.2024; approved after reviewing 18.02.2024; accepted for publication 20.02.2024.
Информация об авторах:
Хайдарова Сарвиноз Хайдаржоновна – докторант кафедры пропедевтики детских болезней, PhD. Самаркандский государственный медицинский университет, Самарканд, Узбекистан. E-mail: sarvinozx88@mail.ru, https://orcid.org/ 0000-0002-2840-6016
Мавлянова Зилола Фархадовна - д.м.н., доцент, заведующая кафедрой медицинской реабилитации, спортивной медицины и народной медицины. Самаркандский государственный медицинский университет, Самарканд, Узбекистан. Е-mail: reab.sammi@mail.ru, https://orcid.org/ 0000-0001-7862-2625
Источники финансирования: Работа не имела специального финансирования.
Конфликт интересов: Авторы декларируют отсутствие явных и потенциальных конфликтов интересов, связанных с публикацией настоящей статьи.
Вклад авторов:
Хайдарова С.Х. - сбор и анализ источников литературы, написание текста
Мавлянова З.Ф. - идеологическая концепция работы, редактирование текста
Information about the authors:
Khaidarоva Kh. Sarvinoz - Doctoral student of the Department of Propaedeutics of Childhood Diseases, PhD. Samarkand state medical university. Samarkand, Uzbekistan; E-mail: sarvinozx88@mail.ru, https://orcid.org/ 0000-0002-2840-6016
Mavlyanova F. Zilola - DSc, associate professor, Head of the department of medical rehabilitation, sports medicine and folk medicine. Samarkand state medical university. Samarkand, Uzbekistan; E-mail: reab.sammi@mail.ru, https://orcid.org/ 0000-0001-7862-2625
Sources of funding: The work did not receive any specific funding.
Conflict of interest: The authors declare no explicit or potential conflicts of interest associated with the publication of this article.
Contribution of the authors:
Khaidarova S.Kh. - collection and analysis of literature sources, writing the text
Mavlyanova Z.F. - ideological concept of the work, editing the article
