MORPHOLOGY AND MORPHOMETRIC INDICATORS OF BRONCHI AND LUNG TISSUES IN CHILDREN WITH BRONCHIECTASIS
Keywords:
бронх, шиллиқ қават, эпителий, бронхоэктаз, киприксимон ҳужайраAbstract
Purpose: To study the morphological and functional characteristics of changes in the bronchial wall and lung tissue obtained during surgery due to bronchiectasis in children.
Methods: 24 patients diagnosed with bronchiectasis were examined, in which fragments of bronchi and lung tissue were removed. The sections sent for histological examination were placed in a 10% neutralized formalin solution and frozen for 72 hours. It was washed with running water and dehydrated with alcohol and chloroform, and paraffin sections were made. Histological sections 5-6 microns thick were made from paraffin sections, paraffin was dissolved in xylene, then the sections were stained with hematoxylin and eosin, Van Gieson and Masson methods, and Alcian blue were used. The relative area occupied by tissue structures in the layers of the bronchial wall was carried out using the "multipoint test" system by G.G. Avtandilov. The statistical discussion was conducted on statistical analysis methods based on MS Office Excel 2007 and STATISTICA software for Windows 10. Pearson coefficient in normal distributions in correlation analysis;
Results: The thickness of the epithelium in the mucous layer in large-caliber bronchi was 76.7 μm, in medium-caliber bronchi it was 60.7 μm, the thickness of the lamina propria of large-caliber bronchi was 24.2 μm, in medium-caliber bronchi it was 19.4 μm. The height of the submucosal layer of the large-caliber bronchi was 114.7 μm, and in the medium-caliber bronchi it was 89.6 μm. Compared to the results in the control group, the thickness of the mucus, lamina propria and submucosal layer of the large-caliber bronchi was found to be thicker by an average of 43.1 μm, and in the medium-caliber bronchi by 26.1 μm.
Conclusion: Changes in the structure of the cells and lamina propria in the bronchial mucosa were profound in bronchiectasis, with metaplasia of goblet cells, hypertrophy and hyperplasia of goblet cells in the mucosa, along with their cystic expansion.
References
Баранов А.А., Намазова-Баранова Л.С., Симонова О.И и другие. Бронхоэктазы у детей: обзор современных клинических рекомендаций // Педиатрическая фармакология. – 2017. – Т.14. №1. - С. 33-42
Блинова С.А., Юлдашева Н.Б., Хотамова Г.Б. Морфофункциональные свойства сосудов легких при бронхоэктатической болезни у детей // Вопросы науки и образования.- 2021. №10 (135). - С. 60-65.
Блинова С.А., Хамидова Ф.М., Исмоилов Ж.М. Изменение структурных компонентов бронхиального секрета при бронхоэктатической болезни у детей // Вопросы науки и образования. Россия, 2019. № 27 (76) С. 16-23.
Блинова С.А., Хамидова Ф.М., Исмоилов Ж.М. Врожденные и приобретенные структуры в легких при бронхоэктатической болезни у детей // Здоровье, демография, экология финно-угорских народов, 2018. № 1. С. 81-83.
Исмоилов Ж.М. Морфологическое особенности легких при бронхоэктатической болезни у детей // Молодежь и медицинская наука в XXI веке. Киров, 2019. С. 65-66.
Клинические рекомендации. Бронхоэктазы у детей. Союз педиатров России 2016.
Самсонова М.В., Черняев А.Л., Леменкова О.С. Бронхоэктазы: современный взгляд на проблему // Практическая пульмонология.- 2017.- №1. - С. 74-80.
Скобелев В.А. Нарушения местного иммунитета при бронхоэктатической болезни у детей // Современные проблемы науки и образования. – 2005. – №2. – С. 12-30.
Степанов А.Б. Бадалян А.Р., Мельникова А.О. Бронхоэктатическая болезнь у детей. // Российский вестник перинатологии и педиатрии. – 2018. - №63 (5). – С. 29–35.
Goyal V., Grimwood К., Мarchant J., Мasters I.B., Chang А.В. Pediatric bronchiectasis: No longer an orphan disease. // Pediatr Pulmonol. – 2016. - №51(5). – Р.450–469.
Guрtа A.K., Lodhа R., Kаbrа S.K. Non Cystic Fibrоsis Вronchiectasis. //Indian. J. Pediatr. – 2015. - №82(10). – Р. 938–44. DOI: 10.1007/s12098-015-1866-4
Наllstrаnd T.S., Наckett T.L., Аltemeier W.А., Мatute-Вello G.,Hansbro P.M.,Knight D.A. Airway Epithelial Regulation of Pulmonary Immune Homeostasis and Inflammation // Clin. Immunol.- 2014- №151 (1). – Р.1-15.
Alimjanovich , R. Z., Maxammatkulovich , R. N., & Khikmatovich , K. K. (2022). Age Features of the Prevalence of Prostate Cancer in Uzbekistan. Central Asian Journal of Medical and Natural Science, 3(5), 154-157. Retrieved from
Rizaev Jasur , Rakhimov Nodir , Kodyrov Khamidullo , Shakhanova Shakhnoza . Study of prostate cancer death by regions of the republic of Uzbekistan.Journal of Biomedicine and Practice. 2022, vol . 7, issue 5, pp.202-210
Shavkatovna S. S., Makhammatkulovich R. N., Ugli M. S. T. ASPECTS OF SARCOPENIA SYNDROME IN ONCOLOGICAL PRACTICE: DIAGNOSIS AND TREATMENT //The American Journal of Medical Sciences and Pharmaceutical Research. – 2024. – Т. 6. – №. 02. – С. 16-25.
Каrаdаg В., Каrаkoc F., Ersu R., Kut А., Вakac S., Dagli Е. Non cystic fibrosis bronchiectasis in children: a persisting problem in developing countries // Respiration. – 2005. - №72. – Р. 233–238.
Кhamidova F.M., Blinova S.А., Ismoilov J.M. Congential and acquired struktures in the lungs of bronchiektasis disease in children. // Вопросы науки и образования. №29 (41), 2018. С. 99-101.
Кhamidova F.M., IJ Mardonovich Nonspecific and specific factors of bronchopulmonary tissue in inflammatory pathology- Journal Of Biomedicine And Practice, 2023
