YO'G'ON ICHAKDAN YARATILGAN SUN'IY QIN SHILLIQ QAVATINING TRANSFORMASIYASI
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сигмовидный кишечник, слизистая оболочка, неовагина, СМРКХ, патоморфологическое исследование##article.abstract##
Dolzarbligi. Jahon sog'liqni saqlash tashkiloti (JSST) ma'lumotlariga ko'ra, ayol jinsiy a'zolarining anomaliyalari resurslari cheklangan mamlakatlarda va oilalarda ko'proq uchraydi. Og'ir malformatsiyalarning 94%ga yaqini past va o'rta daromadli mamlakatlarda uchraydi, bu erda ayollar ko'pincha yomon ovqatlanish va sifatli tibbiy xizmatdan foydalanish imkoniyati yo'q. Neovaginani yaratish uchun ko'p sonli va turdagi jarrohlik aralashuvlarga qaramasdan, hozirgi kungacha morfologik jihatlari to’liq o’rganilmagan.
Maqsad: Sigmasimon ichakdan yaratilgan sun'iy qin devori shilliq qavatining morfologik o'zgarishilarini o'rganish.
Usullari: Neovaginal shilliq qavatning morfofunksional holatini baholash uchun qinning anomaliyalari bo'lgan 28 nafar bemorni gistologik tekshirish uchun, namunalar neovaginani yaratishdan 6 oylik kuzatuvdan so'ng biopsiya materiallari olingan. Operatsiyadan keyingi bemorlarning neovaginasi holati gematoksilin va eozin bilan bo'yash, Van Gizon usuli, Veygert usuli, CHIC bo'yash va Alcian ko'ki bo'yicha bo’yash kabi umumgistologik usullar yordamida o'rganildi.
Olingan natijalar: Gistologik tekshiruv natijalari shuni ko'rsatdiki, neovaginal shilliq qavat butunlay qayta epitelizatsiyalangan va barcha holatlarda taxminan 6 oy ichida glikogen ishlab chiqara boshlagan. Bizning tadqiqotimiz shuni ko'rsatdiki, neovaginaning shilliq qavati barcha holatlarda oddiy vaginaga xos bo'lgan ko'ndalang burmalarsiz tekislangan tuzilishga ega. Bu farq neovaginaning shilliq qavati ostidagi hujayralar va venoz chigallarning etarli emasligi bilan bog'liq. Taxminlarga ko'ra, bu farqlar oddiy qin devoriga nisbatan to'qimalar arxitekturasining o'ziga xos xususiyatlari, vaskulyarizatsiya va neovaginaning innervatsiyasi bilan bog'liq.
Xulosa: Sigmasimon ichakdan hosil bo'lgan neovagina holatini morfologik o'rganish, unda kuzatilgan bir qavatli epiteliyning ko'p qatlamli epiteliyga aylanishidagi strukturaviy o'zgarishlarni baholash bemorlarning neovaginasining omon qolish darajasini taxmin qilish imkonini beradi.
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Статья поступила в редакцию 25.05.2024; одобрена после рецензирования 27.05.2024; принята к публикации 29.05.2024.
The article was submitted 25.05.2023; approved after reviewing 27.05.2024; accepted for publication 29.05.2023.
Информация об авторах:
Хамидова Фарида Муиновна- доктор медицинских наук, доцент, заведующая кафедрой Патологической анатомии с курсом секционной биопсии Самаркандского государственного медицинского университета, E-mail: Хamidovaf.m.05@mail.ru, https://orcid.org/0000-0001-6084-7025.
Якубов Мунис Зокирович - Заведующий кафедрой судебной медицины Самаркандского Государственного медицинского университета, yakubovmunis@gmail.com, https://orcid.org/0000-0002-0449-7566.
Information about the authors:
Khamidova Farida Muinovna - Doctor of Medical Sciences, Associate Professor, Head of the Department of Pathological Anatomy with a course of sectional biopsy of Samarkand State Medical University, E-mail: Хamidovaf.m.05@mail.ru, https://orcid.org/0000-0001-6084-7025.
Yakubov Munis Zokirovich - Head of the Department of Forensic Medicine, Samarkand State Medical University, yakubovmunis@gmail.com, https://orcid.org/0000-0002-0449-7566.
Источники финансирования: Работа не имела специального финансирования.
Конфликт интересов: Авторы декларируют отсутствие явных и потенциальных конфликтов интересов, связанных с публикацией настоящей статьи.
Вклад авторов:
Хамидова Ф.М — идеологическая концепция работы, редактирование статьи;
Якубов М.З — сбор и анализ источников литературы, написание текста.
Sources of funding: The work did not receive any specific funding.
Conflict of interest: The authors declare no explicit or potential conflicts of interest associated with the publication of this article.
Contribution of the authors:
Xamidova FM — ideological concept of the work, writing the text; editing the article;
Yakubov MZ — collection and analysis of literature sources, writing the text.
