TAJRIBA HAYVONLAR MODELIDA ORQA MIY JAROHATI BIOMARKERI S100B NI IMMUNOKIMYOVIY BAHOLASH
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S100B oqsili; orqa miya jarohati; eksperiment; immunoximiya##article.abstract##
Orqa miya travmasiga (OMT) biomarkerlarni joriy etish o'tkir fazada klinik qarorlar qabul qilishni qo'llab-quvvatlash uchun foydali vosita hisoblanadi. S100b asab tizimiga xos deb hisoblangan. OMT holatlarida bu oqsil asab hujayralaridan ajralib chiqadi va turli MNT holatlarida uning konsentratsiyasi orqa miya suyuqligida va qonda ortadi. So'nggi 20 yil davomida OMTdan keyin to'qimalar, zardobda yoki orqa miya suyuqligida S100b ning prognostik roli bo'yicha bir nechta eksperimental va in vivo tadqiqotlar o'tkazildi, natijada bu biomarker orqa miya shikastlanishining dastlabki bosqichlarida real vaqt ko'rsatkichi bo'lishi mumkin degan xulosaga kelindi. Eksperimental tadqiqotlarda zardobdagi va orqa miya suyuqligidagi S100b darajalari qisqa vaqt ichida tez ko'tarildi, keyin asta-sekin pasaydi va jarohatdan bir necha kun o'tgach normal darajaga yetdi. Bundan tashqari, S100b orqa miyaning dastlabki shikastlanishining prediktor sifatida o'rganildi, bu OMT og'irligini to'g'ridan-to'g'ri aks ettiradi. Umurtqa pog'onasi sinishi va orqa miya jarohati bo'lgan bemorlarda ham S100b zardobi darajasining sezilarli o'zgarishlari kuzatildi. S100b oqsili orqa miya jarohatidan keyin orqa miya shikastlanishi darajasini va jarohatdan 14 kun o'tgach nevrologik natijalar darajasini erta aniqlash uchun foydali vosita bo'lishi mumkin.
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