KO‘P PARAMETRLI VIZUALIZATSIYA MA’LUMOTLARINI INTEGRATSIYALASH ASOSIDA BOSH VA BO‘YIN O‘SMALARIDA NUR TERAPIYASINI REJALASHTIRISHNI YUQORI ANIQLIKDA OPTIMALLASHTIRISH
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bosh va bo‘yin o‘smalari, IMRT, VMAT, PET/KT, konturlash, CTV–PTV marjin, geometrik noaniqlik, nur toksikligi, precizion radioterapiya##article.abstract##
Mazkur tadqiqotning maqsadi bosh va bo‘yin o‘smalarida KT, MRT va PET/KT ma’lumotlarini integratsiya qilish asosida nur terapiyasini rejalashtirishning klinik samaradorligi va xavfsizligini baholashdan iborat bo‘ldi. 22 nafar bemor ishtirokida IMRT/VMAT (66–70 Gy) asosida o‘tkazilgan prospektiv-retrospektiv taqqoslama tahlil bajarildi. KT + MRT (n=15) va KT + MRT + PET/KT (n=7) protokollari solishtirildi.
PET/KT qo‘llanilishi sistematik xatolikni (Σ) 3,2 mm dan 1,8 mm gacha, tasodifiy xatolikni (σ) 2,1 mm dan 1,2 mm gacha kamaytirib, CTV–PTV marjini 43% ga qisqartirish imkonini berdi (9,3 mm dan 5,4 mm gacha). 70 Gy yuqori doza hajmi 28% ga kamaydi (p<0,05), miya ustuni va orqa miya doza yuklamasi sezilarli darajada pasaydi. Og‘ir nur toksikligi ortmadi. PTV 66–70 Gy hajmi bilan disfagiya o‘rtasida ijobiy korrelyatsiya (r=0,42; p<0,05), shuningdek, so‘lak bezlari o‘rtacha doza >26 Gy bo‘lganda kserostomiya xavfi oshishi aniqlangan.
Multimodal vizualizatsiya asosidagi matematik jihatdan asoslangan individual marjin qo‘llanilishi nur terapiyasining aniqligini oshiradi va toksiklikni kamaytiradi, onkologik nazoratni saqlagan holda.
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