OG'IZ BO'SHLIG'I SUYUQLIGIDA TRANSFERRIN VA SERULOPLAZMIN KO'RSATKICHLARI ASOSIDA BOLALARDA EKSSUDATIV O'RTA OTITNI BOSQICHMA-BOSQICH TASHXISLASH
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ekssudativ o'rta otit, bolalar, og'iz bo'shlig'i suyuqligi, transferrin, seruloplazmin, sIgA, oksidativ stress, noinvaziv tashxis, mukozal immunitet##article.abstract##
Ushbu tadqiqotda 1–5 yoshli bolalarda ekssudativ o'rta otit (EO'O) sekretli bosqichini tashxislashda og'iz bo'shlig'i suyuqligidagi (OBS) transferrin va seruloplazmin ko'rsatkichlarining diagnostik ahamiyati o'rganilgan. Tadqiqotga EO'O va surunkali adenoiditi bo'lgan 77 nafar bola (asosiy guruh), adenoid giperfiyasiz EO'Osi bo'lmagan 60 nafar bola (qiyosiy guruh) va 35 nafar sog'lom bola (nazorat guruhi) jalb etilgan. OBSda transferrin darajasi asosiy guruhda me'yordan 4 barobar yuqori (12,4±1,1 mg/l), seruloplazmin esa 4 barobar yuqori (4,8±0,5 mg/l) ekanligi aniqlandi. Transferrin darajasi va ekssudatning qovushqoqligi o'rtasida kuchli to'g'ri korrelyatsiya (r=0,74; p<0,01) topildi. Transferrin >12 mg/l va sIgA <0,12 g/l birga bo'lganda «yopishqoq quloq» rivojlanish xavfi 4,5 barobar ortadi. Ushbu ma'lumotlar OBSning biomarkerlari
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