L-PRF-ТЕХНОЛОГИЯСИНИ ЖАҒЛАРНИНГ МЕДИКАМЕНТОЗ-АССОЦИАЦИЯЛАНГАН ОСТЕОНЕКРОЗИНИ КОМПЛЕКС ЖАРРОҲЛИК ДАВОЛАШДА ҚЎЛЛАШ
##article.subject##:
jag‘larning medikamentoz-assotsiatsiyalangan osteonekrozi, JMАON, L-PRF, trombotsitar boyitilgan fibrin, sekvestrektomiya, regeneratsiya, yuz-jag‘ jarrohligi##article.abstract##
Jag‘larning medikamentoz-assotsiatsiyalangan osteonekrozi (JMАON) II bosqichi bo‘lgan 30 nafar bemor ishtirokida retrospektiv tadqiqot o‘tkazildi: 20 nafar bemorga L-PRF qo‘llanilgan holda jarrohlik davolash, 10 nafar bemorga esa L-PRFsiz an’anaviy jarrohlik davolash o‘tkazildi. Guruhlar jins, yosh, zararlanish lokalizatsiyasi va antirezorbtiv terapiya turi bo‘yicha o‘zaro mos edi. Tadqiqot maqsadi — jag‘larning medikamentoz-assotsiatsiyalangan osteonekrozi bilan og‘rigan bemorlarni kompleks jarrohlik davolashda L-PRFning yordamchi komponent sifatida klinik samaradorligini baholashdan iborat. Asosiy guruhda 30 sutkadan keyin shilliq qavatning to‘liq bitishi 100% bemorlarda, taqqoslash guruhida esa 70,0% bemorlarda kuzatildi (p=0,029). L-PRF guruhida operatsiyadan keyingi asoratlar qayd etilmadi, an’anaviy davolashda esa 30,0% bemorlarda aniqlandi (p=0,029). O‘rtacha bitish muddati mos ravishda 30,0±0,0 va 42,0±8,0 sutkani tashkil etdi (p=0,001), bu L-PRFning epitelizatsiyani tezlashtirish va asoratlarni kamaytirishda samaradorligini tasdiqlaydi.
Библиографические ссылки
American Association of Oral and Maxillofacial Surgeons (AAOMS) - Ruggiero S.L., Dodson T.B., Fantasia J. et al. Medication-Related Osteonecrosis of the Jaw-2014 Update. J Oral Maxillofac Surg. 2014;72:1938–1956.
Akkawi I., Zmerly H. Osteoporosis: Current Concepts. Joints. 2018;6(2):122–127.
Otto S., Aljohani S., Fliefel R. et al. Infection as an Important Factor in Medication-Related Osteonecrosis of the Jaw (MRONJ). Medicina. 2021;57:463.
Chang J., Hakam A.E., McCauley L.K. Current Understanding of the Pathophysiology of Osteonecrosis of the Jaw. Current Osteoporosis Reports. 2018;16:584–595.
Schiodt M., Otto S., Fedele S. et al. Workshop of European Task Force on Medication-Related Osteonecrosis of the Jaw-Current Challenges. Oral Diseases. 2019;25:1815–1821.
Di Vito A., Chiarella E., Baudi F. et al. Dose-Dependent Effects of Zoledronic Acid on Human Periodontal Ligament Stem Cells. Cell Transplantation. 2020;29:1–11.
Otto S., Pautke C., Van den Wyngaert T. et al. Medication-Related Osteonecrosis of the Jaw: Prevention, Diagnosis and Management. Cancer Treatment Reviews. 2018;69:177–187.
Campisi G., Mauceri R., Bertoldo F. et al. Medication-Related Osteonecrosis of Jaws (MRONJ) Prevention and Diagnosis: Italian Consensus Update 2020. International Journal of Environmental Research and Public Health. 2020;17:5998.
Hauer L., Jambura J., Hrusak D. et al. Surgical Therapy for Medication-Related Osteonecrosis of the Jaw in Osteoporotic Patients. Biomedical Papers. 2020;164:100–107.
Pedrazzoli M., Autelitano L., Biglioli F. Prevention of Bisphosphonate-Related Mandibular Fractures. Acta Otorhinolaryngologica Italica. 2016;36:317–320.
Werning J.W., Downey N.M., Brinker R.A. et al. The Impact of Osteoporosis on Patients with Maxillofacial Trauma. Archives of Otolaryngology – Head & Neck Surgery. 2004;130:353–356.
Ristow O., Rückschloß T., Müller M. et al. Conservative Non-Surgical Management of MRONJ. Journal of Cranio-Maxillofacial Surgery. 2019;47:491–499.
Turrentine F.E., Wang H., Simpson V.B. et al. Surgical Risk Factors, Morbidity, and Mortality in Elderly Patients. Journal of the American College of Surgeons. 2006;203:865–877.
Aljohani S., Troeltzsch M., Hafner S. et al. Surgical Treatment of Medication-Related Osteonecrosis of the Upper Jaw. Oral Diseases. 2019;25:497–507.
Yamada S.H., Kurita H., Kondo E.M. Treatment Outcomes and Prognostic Factors of MRONJ. Clinical Oral Investigations. 2019;23:3203–3211.
Giudice A., Barone S., Diodati F. et al. Surgical Management of Medication-Related Osteonecrosis of the Jaw. Journal of Oral and Maxillofacial Surgery. 2020;78:1986–1999.
Otto S., Ristow O., Pache C. et al. Fluorescence-Guided Surgery for MRONJ. Journal of Cranio-Maxillofacial Surgery. 2016;44:1073–1080.
Carlson E.R., Basile J.D. Surgical Resection in the Management of Bisphosphonate-Related Osteonecrosis of the Jaws. Journal of Oral and Maxillofacial Surgery. 2009;67:S85–S95.
Giudice A., Bennardo F., Barone S. et al. Can Autofluorescence Guide Surgeons in MRONJ Treatment? Journal of Oral and Maxillofacial Surgery. 2018;76:982–995.
Khosla S., Burr D., Cauley J. et al. Bisphosphonate-Associated Osteonecrosis of the Jaw. Journal of Bone and Mineral Research. 2007;22:1479–1491.
Probst F.A., Metzger M., Ehrenfeld M. et al. CAD/CAM Procedures for Mandibular Reconstruction Plates. Journal of Oral and Maxillofacial Surgery. 2016;74:1879–1895.
Kraeima J., Glas H.H., Witjes M.J.H. et al. Patient-Specific Pre-Contouring of Osteosynthesis Plates. Journal of Cranio-Maxillofacial Surgery. 2018;46:1037–1040.
Dahake S., Kuthe A., Kulkarni S. et al. Finite Element Analysis of Customized Implant in Mandibular Reconstruction. International Journal of Medical Robotics and Computer Assisted Surgery. 2018;14:e1854.
3D Slicer Official Website.
Rendenbach C., Sellenschloh K., Gerbig L. et al. CAD/CAM Plates versus Conventional Fixation Plates for Mandibular Reconstruction. Journal of Cranio-Maxillofacial Surgery. 2017;45:1878–1883.
Martola M., Lindqvist C., Hänninen H. et al. Fracture of Titanium Plates Used for Mandibular Reconstruction. Journal of Biomedical Materials Research Part B. 2007;80:345–352.
Gagnier J.J., Kienle G., Altman D.G. et al. CARE Guidelines: Consensus-Based Clinical Case Report Guideline Development. Journal of Clinical Epidemiology. 2014;67:46–51.
Martins A.S., Correia J.A., Salvado F. et al. Factors Affecting Treatment Outcome and Healing Time in MRONJ. Journal of Cranio-Maxillofacial Surgery. 2017;45:1736–1742.
Fortunato L., Bennardo F., Buffone C. et al. Platelet Concentrates in MRONJ Prevention and Treatment. Journal of Cranio-Maxillofacial Surgery. 2020;48:268–285.
Bucur A., Nita T., Dinca O., Vladan C., Bucur M.B. A case series of osteoporosis patients affected by bisphosphonaterelated osteonecrosis of the jaws. Acta Endocrinol (Buc). 2011;7(4):483–490.
J. A. Rizaev ., A. A. Shodmonov . EditorJournals and Conferences . (2022, October 2). DENTAL IMPLANTATION USING COMPUTER SOFTWARE FOR ACCURATE PLACEMENT AND LONG-TERM PROSTHETIC RESULTS. https://doi.org/10.17605/OSF.IO/DKC6W 19 .
J. A. Rizaev , & A. A. Shodmonov . (2022). OPTIMIZATION OF THE SURGICAL STAGE OF DENTAL IMPLANTATION BASED ON COMPUTER MODELING. World Bulletin of Public Health, 15, 11-13
Rizaev JA, Shodmonov AA Optimizing the Surgical Phase of Dental Implants Optimization of the Surgical Phase of Dental Implantation Based on Computer Modeling //Eurasian Medical Research Periodical. – 2022. – T. 12. – S. 84-87.
Gulmukhamedov , P. B., Rizaev , Zh. A., Khabilov , N. L., & KT, B. (2023, November ). POLYMORPHISM OF THE MTHFR GENE (A1298C) AND CONGENITAL DEFECTS OF THE MAXILLOFACIAL AREA. In Conferences ( pp . 62-63).
Rizaev J., Bekmuratov L. SOCKET SHIELD TECHNIQUE FOR PRESERVING ALVEOLAR SOFT TISSUES DURING IMMEDIATE IMPLANT PLACEMENT //Medical science of Uzbekistan. – 2023. – No. 4. – S. 15-20.
Polatova Djamila , Madaminov Ahmad, Raximov Nodir . Significance of expression PD-L1 and p53 proteins in human papillomavirus-associated oropharyngeal squamous cell carcinoma// Journal of Biomedicine and Practice. 2022, vol . 7, issue 4, pp . 144-151
Abdurakhmonov F. R., Rakhimov N. M., Abdurakhmonova F. F. Special choices for the treatment of complications of the soft tissue injuries of the facial region //The American Journal of Medical Sciences and Pharmaceutical Research. – 2023. – Т. 5. – №. 10. – С. 24-26.
