RADIKAL PROSTATEKTOMIYADAN KEYINGI PERSISTENT SIYDIK TUTA OLMASLIKNING KLINIK VA MORFOLOGIK PREDIKTORLARI
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prostata bezi saratoni, radikal prostatektomiya, siydik tuta olmaslik, postprostatektomik inkontinensiya, xavf omillari, prediktorlar, pad-test##article.abstract##
Tadqiqot maqsadi. Radikal prostatektomiyadan keyingi persistent siydik tuta olmaslikning klinik va morfologik prediktorlarini urologik va onkologik xavf omillari asosida aniqlash.
Materiallar va usullar. Prostata bezi saratoni tufayli radikal prostatektomiya o‘tkazilgan 501 nafar bemor ishtirokida bir markazli retrospektiv tadqiqot amalga oshirildi. Asosiy yakuniy nuqta operatsiyadan 12 oy o‘tgach klinik ahamiyatli siydik tuta olmaslikning mavjudligi bo‘ldi. Mustaqil prediktorlarni aniqlash uchun ko‘p omilli logistik regressiya tahlili qo‘llanildi.
Natijalar. O‘smaning noqulay morfologik xususiyatlari persistent siydik tuta olmaslikning yuqori uchrashishi bilan bog‘liq ekanligi aniqlandi. Klinik ahamiyatli siydik tuta olmaslikning mustaqil prediktorlari: yosh ≥70 yil (OR=1,7; 95% DI 1,2–2,4), pT3–4 bosqichi (OR=1,5; 95% DI 1,1–2,1), pN1-status (OR=1,5; 95% DI 1,0–2,2) hamda pad-test bo‘yicha >18 g bo‘lgan erta operatsiyadan keyingi siydik tuta olmaslik (OR=3,8; 95% DI 2,3–6,0) bo‘ldi. Eng yuqori prognostik ahamiyat erta operatsiyadan keyingi siydik tuta olmaslikda kuzatildi.
Xulosa. Radikal prostatektomiyadan keyingi persistent siydik tuta olmaslik klinik va morfologik omillarning birgalikdagi ta’siri bilan belgilanadi. Yosh ≥70 yil, pT3–4 bosqichi, pN1-status va pad-test >18 g noqulay funksional natijaning muhim prediktorlari hisoblanadi.
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