METABOLIK SINDROMLI BEMORLARDA VAHIMALI VA DEPRESSIV BUZILISHLARNING KLINIK AHAMIYATI
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vahima, depressiya, metabolik sindrom, semirish, davolash xususiyatlari##article.abstract##
Hozirgi vaqtda depressiya metabolik sindrom rivojlanishining qo'zg'atuvchilaridan biri sifatida tobora ko'proq ko'rilmoqda. Buning sababi shundaki, affektiv buzilishlar Butunrossiya kardiologiya ilmiy jamiyatining metabolik sindromni tashxislash va davolash bo'yicha tavsiyalariga muvofiq metabolik kasalliklarning rivojlanishiga olib keladigan xavf omillarini shakllantirishga yordam beradi. Asosiy xavf omillari: ortiqcha ovqatlanish, jismoniy harakatsizlik va gipertoniya. Darhaqiqat, depressiya holatida jismoniy faollik pasayadi, ishtaha kuchayadi va simpatik asab tizimining giperreaktivligi (simpatikotonik sindrom) qon bosimini ko'tarish uchun qo'zg'atuvchi omil hisoblanadi. Depressiya va metabolik sindrom o'rtasidagi bog'liqlik "ikki tomonlama ko'cha" ekanligi 2009 yilda T. N. Akbaraliya va boshqalar tomonidan o'tkazilgan Whitehall II kohort tadqiqotining natijalari bilan tasdiqlangan. Epidemiologik tadqiqotlar hozirda juda katta hajmdagi metabolik sindromli bemorlarning namunalari ma'lumotlari bilan taqdim etilgan. Eng vakili 2004 yilda L. S. Kinder va boshqalar tomonidan nashr etilgan tadqiqotlardir. 6 yil davomida to'plangan materialni tahlil qilgan ish mualliflarining ta'kidlashicha, 17 yoshdan 39 yoshgacha bo'lgan 3003 nafar tekshirilgan odamlar guruhida metabolik sindromli odamlarning ulushi depressiv buzilish epizodi bo'lgan hollarda 2 baravar yuqori. L. Vitterberg va boshqalar. depressiv kasalliklarga chalingan bemorlarda "past melatonin sindromi" tushunchasi taklif qilingan. Ushbu modelga ko'ra, melatoninning past darajasi miyada norepinefrin va serotonin darajasining pasayishining asosiy sababi bo'lishi mumkin va bilvosita gipotalamus-gipofiz tizimining disfunktsiyasiga ta'sir qilishi mumkin, bu esa o'z navbatida depressiv kasalliklarning rivojlanishiga moyillik belgisi sifatida ishlatilishi mumkin. Shu bilan birga, melatoninning dismetabolizm rivojlanishidagi rolini muhokama qiladigan ishlar mavjud. So'nggi yillarda metabolik sindromli bemorlar sonining ko'payishi kuzatilmoqda, bu jiddiy tibbiy muammo. Metabolik sindromning klinik ko'rinishlarining og'irligi bemorlarning hayot sifatiga ta'sir qiladi, jismoniy va ruhiy salomatlik ko'rsatkichlari pasayadi. Semirib ketish Anksiyete kasalliklariga, nevrozga o'xshash holatlarga va depressiyaga olib keladi, bu esa asosiy kasallikning yomonlashishiga yordam beradi. Mavjud klinik va eksperimental dalillar tashvish va depressiv kasalliklarga chalingan odamlarda metabolik sindromning paydo bo'lish ehtimoli yuqori ekanligini tushuntiruvchi bir nechta patofiziologik bog'lanishlar mavjudligini aniq ko'rsatadi.
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Статья поступила в редакцию 03.03.2024; одобрена после рецензирования 20.04.2024; принята к публикации 26.04.2024.
The article was submitted 03.03.2024; approved after reviewing 20.04.2024; accepted for publication 26.04.2024.
Информация об авторах:
Толиб М. Тураев — аспирант Самаркандского государственного медицинского университета. Самаркандия, Узбекистан; E-mail: tolibturaev544@gmail.com, https://orcid.org/0009-0003-2861-6579
Чарос А. Кучимова — кандидат медицинских наук, ассистент Самаркандского государственного медицинского университета. Самаркандия, Узбекистан; E-mail:charos_kuchimova@mail.ru, https://orcid.org/0000-0001-8352-3744
Источники финансирования: Работа не получила какого-либо специального финансирования.
Конфликт интересов: Авторы заявляют об отсутствии явных или потенциальных конфликтов интересов, связанных с публикацией данной статьи.
Вклад авторов:
Тураев Т.М. — идеологическая концепция работы, написание текста; редактирование статьи;
Кучимова Ч.А — сбор и анализ литературных источников, написание текста.
Information about the authors:
Tolib M. Turaev — basic doctoral student of Samarkand state medical university. Samarkand, Uzbekistan; E-mail: tolibturaev544@gmail.com, https://orcid.org/0009-0003-2861-6579
Charos A. Kuchimova — PhD, assistant of Samarkand state medical university. Samarkand, Uzbekistan; E-mail:charos_kuchimova@mail.ru, https://orcid.org/0000-0001-8352-3744
Sources of funding: The work did not receive any specific funding.
Conflict of interest: The authors declare no explicit or potential conflicts of interest associated with the publication of this article.
Contribution of the authors:
Turaev T.M — ideological concept of the work, writing the text; editing the article;
Kuchimova Ch.A — collection and analysis of literature sources, writing the text.
