ASSESSMENT OF THE SEVERITY OF ACUTE OBSTRUCTIVE BRONCHITIS AND BRONCHIOLITIS IN EARLY CHILDREN DEPENDING ON THE LEVEL OF OXIPROLIN IN THE BLOOD
Keywords:
oxyproline, bronchitis and bronchiolitis, immunomodulin, treatment, childrenAbstract
The article presents data on the state of collagen metabolism in terms of oxyproline in the blood, its clinical significance for assessing the severity and outcome of the disease, the criterion for the effectiveness of therapy in children of early age with acute obstructive bronchitis and bronchiolitis. The author recommends to determine the level of free and protein-bound oxyproline in blood plasma, an increase in which reflects the degree of destruction in the bronchopulmonary apparatus. The inclusion of immunomodulin into the basic treatment contributes to an increase in the effectiveness of therapy, a reduction of treatment duration.
References
L. Petrarca, T. Jacinto //The treatment of acute bronchiolitis: past, present and future//Breathe (Sheff). 2017 Mar; 13(1): e24–e26. doi: 10.1183/20734735.000717.
National Institute for Health and Care Excellence. Bronchiolitis in children. NG9 London, National Institute for Health and Clinical Excellence, 2015.
Maguire C., Cantrill H., Hind D, et al. Hypertonic saline (HS) for acute bronchiolitis: systematic review and meta-analysis. BMC Pulm Med 2015; 15: 148.
Gadomski A.M., Scribani M.B. Bronchodilators for bronchiolitis. Cochrane Database Syst Rev 2014; CD001266.
Farley R., Spurling G. et al. . Antibiotics for bronchiolitis in children under two years of age. Cochrane Database Syst Rev 2014; CD005189.
Fernandes R.M., Bialy L.M. et al. . Glucocorticoids for acute viral bronchiolitis in infants and young children. Cochrane Database Syst Rev 2013; CD004878.
Jat K.R., Chawla D. Surfactant therapy for bronchiolitis in critically ill infants. Cochrane Database Syst Rev 2015; CD009194.
Beggs S., Wong Z.H., Kaul S. et al. . High-flow nasal cannula therapy for infants with bronchiolitis. Cochrane Database Syst Rev 2014; CD009609.
Heikkilä P., Forma L., Korppi M. High-flow oxygen therapy is more cost-effective for bronchiolitis than standard treatment-A decision-tree analysis. Pediatr Pulmonol 2016; 51: 1393–1402.
Graham B.S. Vaccines against respiratory syncytial virus: the time has finally come. Vaccine 2016; 34: 3535–3541.]
Chiu C. Novel immunological insights in accelerating RSV vaccine development. Vaccine 2017; 35: 459–460. [PubMed] [Google Scholar]
Simões E.A., De Vincenzo J.P., Boeckh M., et al. Challenges and opportunities in developing respiratory syncytial virus therapeutics. J Infect Dis 2015; 211: Suppl. 1, S1–S20.
Enriquez A., Chu I.W., Mellis C., et al. Nebulised deoxyribonuclease for viral bronchiolitis in children younger than 24 months. Cochrane Database Syst Rev 2012; 11: CD008395.
Nenna R., Tromba V., Berardi R. et al. . Recombinant deoxyribonuclease treatment in hospital management of infants with moderate-severe bronchiolitis. Eur J Inflammation 2009; 7: 169–174.
R.Reyes , G. Rugeles , Ch. Anzola LP.|| Oxygen therapy for lower respiratory tract infections in children between 3 months and 15 years of age|| Cochrane Database Syst Rev. 2014 Dec 10;2014(12):CD005975. doi:
1002/14651858.CD005975.pub3.
Skjerven H.O., Rolfsjord L.B., Berents T.L. et al.|| Allergic diseases and the effect of inhaled epinephrine in children with acute bronchiolitis: follow-up from the randomised, controlled, double-blind, Bronchiolitis ALL trial.|| Lancet Respir Med. 2015 Sep;3(9):702-708. doi: 10.1016/S2213-2600(15)00319-7. Epub 2015 Aug 25.
Stafler P et al.|| Feasibility of multiple breath washout measurements in infants with bronchiolitis: A pilot study|| Pediatr Pulmonol. 2017 Jun;52(6):763-770. doi: 10.1002/ppul.23674. Epub 2017 Feb 21..
Teixeira M.F.C, Rodrigues J.C. et al. || Acute bronchodilator responsiveness to tiotropium in postinfectious bronchiolitis obliterans in children.|| Chest. 2013 Sep;144(3):974-980. doi: 10.1378/chest.12-2280.
Usenko S.H., Yeloeva Z.V. et al. || Clinical and laboratory aspects of acute obstructive bronchitis in children infected with mycoplasma pneumonia||Wiad Lek. 2020;73(6):1229-1233.
Xing Y., Proesmans M.|| New therapies for acute RSV infections: where are we?||
Eur J Pediatr. 2019 Feb;178(2):131-138. doi: 10.1007/s00431-018-03310-7. Epub
Jan 4.
Zhao C., Liu J., Yang H., Xiang L., Zhao S.|| Mycoplasma pneumoniae-Associated Bronchiolitis Obliterans Following Acute Bronchiolitis|| Sci Rep. 2017 Aug 16;7(1):8478. doi: 10.1038/s41598-017-08861-7.
