COMPARATIVE CHARACTERISTICS OF LABORATORY MARKERS IN PATIENTS WITH SILICOSIS WITH LOW AND PRESERVED LVEF
Keywords:
silicosis, echocardiography, endothelin-1, TNF-a, diastolic dysfunction, ejection fractionAbstract
The article is devoted to the early diagnosis of disorders of the central and intracardiac hemodynamics in patients suffering from silicosis. Identification of the associated relationships of systemic inflammation with changes in the parameters of echocardiographic data and endothelial dysfunction. In the course of the study, a correlation analysis of the relationship between LV EF and various indicators characterizing pathogenetic changes in patients with silicosis was carried out, namely the activation of a systemic inflammatory response, which was reflected in the present study by the activity of myeloperoxidase, neutrophil elastase and the concentration of pro-inflammatory cytokines TNF-alpha, interleukin-8 and the concentration of endothelin 1, reflecting the violation of the functional state of the endothelium.
References
Bershtein L.L. Echocardiography in coronary heart disease // L.L. Berstein. - M.: GEOTAR- Media, 2016. - 0 p.
Rybakova, M.K. Differential diagnosis in echocardiography (+ DVD-ROM) / M.K. Rybakova, V.V. Mitkov. - Moscow: Higher School, 2011. - 232 p.
Chernyaeva M.S., Ostroumova O.D. Target levels of blood pressure in patients with arterial hypertension and coronary heart disease // Arterial hypertension. - 2020. - No. 26 (1). - pp.15- 26.
Vlasova S.P., Ilchenko M.Yu., Kazakova E.B. Endothelial dysfunction and arterial hypertension // - M.: Medicine, 2010. - pp. 235-238.
Baraeva R.A. Vasomotor function of the endothelium and the content of endothelin-1 in patients with vibration disease and in combination with arterial hypertension // Occupational Medicine and Industrial Ecology. - 2017. - No. 9. - P.19-20.
Babanov S.A., Baraeva R. Occupational lesions of the cardiovascular system // Vrach. - 2015. - No. 3. - pp. 7-10.
Ageenkova O.A., Purygina M.A., Milyagin V.A. Structural and functional changes in the heart and blood vessels in patients with arterial hypertension and coronary heart disease // Modern problems of science and education. - 2013. - No. 5. - P. 292.
Mayanskaya S.D., Antonov A.R., Popova A.A., Grebenkina I.A. Early markers of endothelial dysfunction in the dynamics of the development of arterial hypertension in young people // Kazan medical journal. 2009; 90 (1): 32–37.
Vlasova S.P., Ilchenko M.Yu., Kazakova E.B. Endothelial dysfunction and arterial hypertension // - M.: Medicine, 2010. - pp. 235-238.
Tashmukhamedova M.K. Prevention of diseases of the cardiovascular system among workers in the mining industry // Cardiology of Uzbekistan. - 2020. - No. 3. - p. 46.
