SPESIFIC FFEATURES OF NEUROLOGICAL SYMPTOMS IN PATIENTS WITH SUBCLINICAL HYPOTERIOSIS
Keywords:
subclinical hypothyroidism, neurological symptoms, depression, stress, neurological tests, cognitive function, headache, insomnia, dizziness, emotional disorders.Abstract
Subclinical hypothyroidism is a widespread endocrine disorder that often remains undiagnosed. The latent course of this condition, especially its manifestation through neurological symptoms, has garnered increasing attention in clinical practice. This study examined the prevalence of neurological disorders, as well as their distribution by age and gender, in a cohort of 80 patients with subclinical hypothyroidism. According to the results, at least one neurological symptom was identified in 76% of the patients, with the most common being headache (48%), paresthesia (42%), and insomnia (39%). The majority of these symptoms were observed in women aged 31–50 years. These findings provide a basis for developing new approaches to early detection of subclinical hypothyroidism through neurological symptoms.
References
Norqobilov M.N., Saidova G.M. Qalqonsimon bez faoliyatining buzilishi va asab tizimi o‘zaro bog‘liqligi // “Tibbiyotda innovatsiyalar”, 2020, №3. – 44–47-betlar.
Xamidova N.N. Qalqonsimon bez kasalliklari va ular bilan bog‘liq nevrologik sindromlar // “Tibbiy ta’limda yangiliklar”, 2022, №2. – 39–42-betlar.
Sharipova M.T. Subklinicheskiy gipoterioz: Sovremenniy vzglyad na diagnostiku i lecheniye // “Tibbiyot va amaliyot”, 2023, №1(7). – 33–36-betlar.
American Thyroid Association. (2021). Guidelines for the treatment of hypothyroidism. https://www.thyroid.org
Bauer, M., et al. (2002). Thyroid hormones and mood disorders. International Journal of Neuropsychopharmacology, 5(2), 193–202.
Bianco, A. C., et al. (2002). Thyroid hormone regulation and brain development. Nature Reviews Endocrinology, 8(1), 22–33.
Biondi, B., Cooper, D. S. (2008). The clinical significance of subclinical thyroid dysfunction. Endocrine Reviews, 29(1), 76–131.
Canaris, G. J., et al. (2000). The Colorado thyroid disease prevalence study. Archives of Internal Medicine, 160(4), 526–534.
Demartini, B., et al. (2020). Thyroid dysfunction and headache: A review. Journal of Clinical Neuroscience, 73, 45–49.
Joffe, R. T., & Levitt, A. J. (1992). Major depression and subclinical (compensated) hypothyroidism. Psychoneuroendocrinology, 17(2–3), 215–221.
Langer, R., et al. (2018). Neurological manifestations of subclinical hypothyroidism. Endocrine Practice, 24(3), 268–275.
Larisch, R., et al. (2015). Cognitive deficits in subclinical hypothyroidism: A neuropsychological study. Thyroid, 25(12), 1317–1323.
Rizos, C. V., et al. (2011). Association of subclinical hypothyroidism with lipid profile, cardiovascular risk, and cognitive function. Hormones, 10(3), 287–294.
Surks, M. I., et al. (2004). Subclinical thyroid disease: Scientific review and guidelines for diagnosis and management. JAMA, 291(2), 228–238.
Shimomura, T., et al. (2017). Peripheral neuropathy in hypothyroid patients: Clinical and electrophysiological studies. Journal of Neurology, 264(4), 679–685.
Vanderpump, M. P. J. (2011). The epidemiology of thyroid disease. British Medical Bulletin, 99(1), 39–51.
WHO. (2022). Global prevalence of thyroid disorders and impact on population health. Geneva: World Health Organization.
Zulewski, H., et al. (1997). Subclinical hypothyroidism in hospital patients: Clinical implications. Journal of Clinical Endocrinology & Metabolism, 82(2), 359–363.
