NON-MOTOR SYMPTOMS OF PARKINSON'S DISEASE: CLINICAL SIGNIFICANCE AND THERAPEUTIC APPROACHES
Keywords:
Parkinson’s disease, non-motor symptoms, pramipexole, cognitive impairment, depression, autonomic dysfunction, quality of lifeAbstract
A total of 100 patients with Parkinson’s disease at stages I–III according to the Hoehn and Yahr scale, receiving outpatient care, were examined. All patients underwent comprehensive clinical-neurological and neuropsychological assessments with a focus on identifying non-motor symptoms. The NMSS, HADS, UPDRS, and PDQ-39 scales were used for evaluation. A comparative observation of the effectiveness of standard therapy and therapy with the addition of pramipexole was conducted. Patients receiving pramipexole as part of combination therapy showed a more significant reduction in anxiety-depressive, autonomic, and cognitive impairments. Improvement in sleep and general psycho-emotional status was also observed.
References
Marras C., Chaudhuri K.R. Nonmotor features of Parkinson’s disease subtypes // Movement Disorders. – 2022. – Т. 37, № 6. – С. 1042– 1055. – DOI: 10.1002/mds.29035.
Barone P., Erro R., Picillo M., et al. The Non-Motor Symptoms Scale: validation and use // Frontiers in Aging Neuroscience. – 2022. – Т. 14. – Ст. 887094. – DOI: 10.3389/fnagi.2022.887094.
Stocchi F., Torti M. Adjuvant therapies for Parkinson’s disease: dopamine agonists and MAO-B inhibitors // Parkinsonism and Related Disorders. – 2017. – Т. 34. – С. 47–52. – DOI: 10.1016/j.parkreldis.2016.10.013.
Titova N., Chaudhuri K.R. Personalized medicine in Parkinson’s disease: Time to be precise // Movement Disorders. – 2017. – Т. 32, № 8. –
С. 1147–1154. – DOI: 10.1002/mds.27027.
Kalia L.V., Lang A.E. Parkinson’s disease // Lancet. – 2015. – Т. 386, № 9996. – С. 896–912. – DOI: 10.1016/S0140-6736(14)61393-3.
Zang Y., et al. Non-Pharmacological Interventions for Non-Motor Symptoms of Parkinson’s Disease: A Systematic Review // Brain Sciences. – 2023. – Т. 13, № 5. – Ст. 776. – DOI: 10.3390/brainsci13050776.
Zhang L., et al. Early Dopaminergic Treatment Benefits Motor and Non-Motor Symptoms in Parkinson’s Disease // Frontiers in Human Neuroscience. – 2024. – Т. 18. – Ст. 1325324. – DOI: 10.3389/fnhum.2024.1325324.
Aarsland D., et al. Under-treatment of Non-Motor Symptoms in Parkinson’s Disease: Results from a Large Cross-Sectional Study // Parkinsonism and Related Disorders. – 2023. – Т. 109. – Ст. 105361. – DOI: 10.1016/j.parkreldis.2023.105361.
