SOD2, EDN1 ВА eNOS ГЕНЛАРИ ПОЛИМОРФИЗИМЛАРИНИНГ ЦЕРЕБРОВАСКУЛЯР КАСАЛЛИКЛАРНИНГ РИВОЖЛАНИШИДА ЎЗАРО ТАЪСИРИ
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COVID-19, психоневрологик касалликлар, тиббий реабилитатсия, физиотерапия, рефлексология, анъанавий шарқ гимнастикаси##article.abstract##
Мақола SOD2 (Ala16Val), EDN1 (Lys197Asn) ва eNOS (T786C) генлари полиморфизмларнинг ўзаро таъсири цереброваскуляр касалликлар (ЦВК) ривожланишидаги аҳамиятини ўрганишга бағишланган. Асосий эътибор шундаки, ушбу генетик вариантларнинг ҳақиқий патогенетик аҳамияти уларнинг алоҳида таъсирида эмас балки уларнинг синергизми орқали намоён бўлади.
Тадқиқот натижалари. SOD2: Val/Val генотипи МҚТК юқори ҳавфи билан аҳамиятли боғлиқ экани аниқланган (OR=3,3; p=0,01). Val/Val ва Val/Ala генотиплари комбинацияси хавфни янада оширган. EDN1: Asn аллели ва Asn/Asn генотипи ЦВК хавфини ошириши билан боғлиқлиги қайд этилган бўлиб, улар юқори сезгирликка (SE=0,71–0,81) эгп, аммо паст махсусликга (SP=0,23–0,29) эгалиги сабабли мустақил диагностик қийматни чеклайди. eNOS: T786C полиморфизмининг инсульт билан боғлиқлиги статистик жиҳатдан аҳамиятсиз бўлиб чиқган (OR=0,88; p=0,65). C/C ва C/T генотиплари паст махсусликка эга (SP=0,25). комбинацияланган таъсир. Ҳар қандай ген бўйича битта салбий генотип мавжудлиги ҳам ЦВК хавфини статистик жиҳатдан оширади (OR=2,48; p=0,006). Салбий генотиплар сонига мутаносиб равишда хавфнинг ошиши аниқланган. Энг кучли таъсир учала салбий генотип биргаликда учраганда кузатилган (OR=2,92; p=0,061).
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