PREDICTION OF PAIN SYNDROME IN POSTHERPETIC NEURALGIA BASED ON CLINICAL SYMPTOMS AND BLOOD BIOMARKERS
Keywords:
postherpetic neuralgia, pain syndrome, biomarkers, prediction, inflammatory cytokines, neuropeptides, herpes zoster, chronic painAbstract
Postherpetic neuralgia (PHN) represents one of the most severe complications of herpes zoster, characterized by persistent pain syndrome that significantly reduces patients' quality of life. Traditional approaches to predicting PHN development were based predominantly on clinical risk factors such as age, severity of the acute phase, and lesion localization. However, modern studies demonstrate the necessity of an integrated approach, including analysis of biomarkers of inflammation, neurodegeneration, and pain sensitivity for more accurate prediction of disease course. The aim of the study is to develop a comprehensive prognostic model for pain syndrome development in PHN based on a combination of clinical parameters and laboratory blood biomarkers.
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Вклад авторов
Сулаймонов Муроджон Насирович внес основной вклад в разработку концепции исследования, сбор и анализ клинических данных, статистическую обработку результатов и подготовку рукописи. Хайдарова Дилдора Кодировна участвовала в планировании исследования, интерпретации результатов, критическом анализе и редактировании текста статьи. Оба автора принимали активное участие в обследовании и лечении пациентов, согласились принять ответственность за все аспекты работы и одобрили окончательную версию публикации.
Mualliflar hissasi
Sulaymanov Murodjon Nasirovich tadqiqot konsepsiyasini ishlab chiqish, klinik ma'lumotlarni yig'ish va tahlil qilish, natijalarni statistik qayta ishlash va qo'lyozmani tayyorlashda asosiy hissa qo'shdi. Haydarova Dildora Qodirovna tadqiqotni rejalashtirish, natijalarni talqin qilish, tanqidiy tahlil va maqola matnini tahrirlashda ishtirok etdi. Ikkala muallif ham bemorlarni tekshirish va davolashda faol qatnashdi, ishning barcha jihatlari uchun javobgarlikni o'z zimmasiga olishga rozi bo'ldi va nashrning yakuniy nusxasini ma'qulladi.
AUTHORS CONTRIBUTIONS
Sulaymanov Murodjon Nasirovich made the primary contribution to the development of the research concept, collection and analysis of clinical data, statistical processing of results, and manuscript preparation. Haydarova Dildora Kodirovna participated in research planning, results interpretation, critical analysis, and text editing of the article. Both authors actively participated in patient examination and treatment, agreed to take responsibility for all aspects of the work, and approved the final version of the publication.
