ASSESSMENT OF COGNITIVE FUNCTIONS IN PATIENTS WITH HYPOTHYROIDISM
Keywords:
аутоиммун тиреоидит, гипотиреоз, когнитив нарушениe, опросника АдденбрукаAbstract
This article examines the relationship between thyroid dysfunction and cognitive impairment, with a focus on hypothyroidism. The study involved 80 women with long-standing disease, divided into two subgroups: those with autoimmune thyroiditis and those in a post-total thyroidectomy state. Cognitive status was assessed using the Addenbrooke’s Cognitive Examination. The results showed that cognitive impairments were more frequent and pronounced in patients after thyroidectomy compared to those with autoimmune hypothyroidism. This is attributed to a more severe hormonal imbalance and reduced T3 levels in the brain due to levothyroxine monotherapy. The authors emphasize the importance of early detection of cognitive deficits and the need for individualized hormone replacement therapy to improve patients’ quality of life.
References
Beydoun, M.A.; Beydoun, H.A.; Rostant, O.S.; Dore, G.A.; Fanelli-Kuczmarski, M.T.; Evans, M.K.; Zonderman, A.B. Thyroid Hormones Are Associated with Longitudinal Cognitive Change in an Urban Adult Population. Neurobiol. Aging 2015, 36, 3056–3066. [Google Scholar] [CrossRef] [PubMed]].
Bernal, J. Thyroid Hormone Regulated Genes in Cerebral Cortex Development. J. Endocrinol. 2017, 232, R83–R97. [Google Scholar] [CrossRef
Chen, Z.; Liang, X.; Zhang, C.; Wang, J.; Chen, G.; Zhang, H.; Sun, Z. Correlation of Thyroid Dysfunction and Cognitive Impairments Induced by Subcortical Ischemic Vascular Disease. Brain Behav. 2016, 6, e00452. [Google Scholar] [CrossRef]
Eslami-Amirabadi, M.; Sajjadi, S.A. The Relation between Thyroid Dysregulation and Impaired Cognition/Behaviour: An Integrative Review. J. Neuroendocrinol. 2021, 33, e12948. [Google Scholar] [CrossRef
Global Mortality from Dementia: Application of a New Method and Results from the Global Burden of Disease Study 2019. Alzheimer’s Dement. Transl. Res. Clin. Interv. 2021, 7, e12200. [CrossRef] [PubMed
Gujski, M.; Pinkas, J.; Witczak, M.; Owoc, A.; Bojar, I. Modele Funkcji Poznawczych Względem Wybranych Parametrów Stanu Funkcjonalnego Tarczycy u Kobiet Po Menopauzie. Endokrynol. Pol. 2017, 68, 290–298. [Google Scholar] [CrossRef
Kaur, H.; Malhotra, N.; Jacob, J.J. Impact of Subclinical Hypothyroidism on Cognitive Functions among the Elderly. Aging Health Res. 2021, 1, 100014. [Google Scholar
Kayumova N.K., Nazarova J.A., Mamadinova L.Kh., Abbosova I.A., & Abduvalieva G.T. (2023). Assessment Of Quality Of Life And Cognitive Function In Patients With Primary Hypothyroidism. Journal of Population Therapeutics and Clinical Pharmacology, 30(14), 249-255. https://doi.org/10.47750/jptcp.2023.30.14.033
Khaleghzadeh-Ahangar, H.; Talebi, A.; Mohseni-Moghaddam, P. Thyroid Disorders and Development of Cognitive Impairment: A Review Study. Neuroendocrinology 2022, 112, 835–844. [Google Scholar] [CrossRef] [PubMed
Salwa Seddik Hosny El-khwaga; Dina Ahmed Marwan; Nahla Nader Adly; Marina El-Amir Hakim; Ahmed Mohamed Bahaaeldin Effect of Levothyroxine Replacement on Cognitive Function Impairment in a Sample of Egyptian Population with Subclinical Hypothyroidism Dubai Diabetes Endocrinol J (2022) 28 (3): 93–101. https://doi.org/10.1159/000525609
Wang, Y.; Xu, H.; Geng, Z.; Geng, G.; Zhang, F. Dementia and the History of Disease in Older Adults in Community. BMC Public Health 2023, 23, 1555. [Google Scholar] [CrossRef
van Vliet, N.A.; van Heemst, D.; Almeida, O.P.; Åsvold, B.O.; Aubert, C.E.; Bae, J.B.; Barnes, L.E.; Bauer, D.C.; Blauw, G.J.; Brayne, C.; et al. Association of Thyroid Dysfunction With Cognitive Function. JAMA Intern. Med. 2021, 181, 1440. [Google Scholar] [CrossRef
