THE ROLE OF MIR-21 IN THE REGULATION OF GENE EXPRESSION IN ISCHEMIC BRAIN INJURY
Keywords:
stroke, miR-21, IL-6, TNF-α, expression, DGLA, PLA2GE2, PADI4Abstract
Stroke is an acute cerebrovascular accident resulting in persistent focal brain damage. Post-transcriptional regulators of gene expression can signal the severity of the disease, thereby facilitating timely treatment adjustments A relationship has been established between the blood biomarkers DGLA, PLA2GE2, PADI4, and miR-21, whose levels may signal the outcome of rehabilitation procedures. This requires a systematic approach to their study.. Although numerous potential stroke bio- markers have been recently proposed, none have yet found application in routine clinical practice.
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