STRUCTURE OF INTERRELATIONSHIPS AND PATHOGENETIC PATTERNS OF NEUROLOGICAL MANIFESTATIONS IN SPINAL PATHOLOGY: BASED ON CORRELATION ANALYSIS OF CLINICAL-BIOCHEMICAL INDICATORS
Keywords:
degenerative spinal diseases, neurological manifestations, correlation analysis, pathogenesis, degenerative process, inflammatory process, matrix metalloproteinases, C-reactive protein, interleukin-6Abstract
The article presents the results of a correlation analysis aimed at identifying the structure of interrelationships and pathogenetic patterns of neurological manifestations in spinal pathology. The study established the presence of a structured network of correlations between clinical symptoms and the levels of key biochemical markers. The key scientific result was the identification of two interconnected but relatively independent pathogenetic processes: degenerative (MMP-mediated) and inflammatory-neuropathic (CRP/IL-6-mediated). The obtained data convincingly confirm the necessity of a comprehensive assessment of patients, taking into account both indicated components of pathology.
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