THE ROLE OF BIOMARKERS OF THE TERRITORIAL STADE OF PARKINSONꞌS DISEASE IN THE PROGRESSION OF THE DISEASE
Keywords:
Parkinson's disease, olfactory function, brain, hyposmia, anosmiaAbstract
The article presents the results of observation of 213 patients with PD, including 90 (42.25%) women, 123 (57.75%) men, whose mean age was 46.17±0.63 years. Patients with PD were selected in accordance with the international criteria of the British brain bank "Parkinson's Disease Society Brain Bank". Patients underwent CT or MRI of the brain. Olfactory disturbances were studied using the Sniffin Stix Test (SST) by Burchard (Hamburg, Germany). All patients underwent examination of the ENT organs. The results obtained indicate that the presence of hyposmia in patients with early onset of PD is an important biomarker of the latent neurodegenerative process of the “Parkinsonian” type and, therefore, the risk of future development of PD.
References
Даминова Х.М. Современный взгляд к оптимизации диагностики течения болезни Паркинсона.// Journal "New Day in Medicine" .- Avicenna-Med.uz.-.-№1 (39) .- 2022-January- March.-s. 115-119.
Морозова С.В., Савватеева Д.М., Лопатин А.С. Расстройства обоняния и их коррекция // Вестник оториноларингологии. - 2012. - № 5. - С. 66-70.
Пономарев В.В. Лабораторные биомаркеры ранней диагностики болезни Паркинсона / В.В. Пономарев, А.В. Бойко, О.А. Ионова //International neurological journal. – 2016. – №3 (81). – с. 54-58.
Шток В.Н., Федорова Н.В. Болезнь Паркинсона // Экстрапирамидные расстройства: рук-во по диагностике и лечению / под ред. В.Н. Штока, И.А. Ивановой-Смоленской, О.С. Левина. М.: Медпресс-информ, 2012. С. 87–124.
Alonso-Navarro H., Jimenez-Jimenez F.J., Garcia-Martin E., Agundez J.A.G. Genomic and pharmacogenomics biomarkers of Parkinson's disease // Cur. Drug Metab. 2014. - Vol. 15. - P. 129-181.
Braak H. Staging of brain pathology related to sporadic Parkinson's disease / Braak H., Del Tredici K., Rüb U., de Vos R.A.I., Jansen Steur E.N.H, Braak // Neurobiol Aging.–2013–Vol.24–р.197–210.
Duda J.E. Olfactory system pathology as a model of Lewy neurodegenerative disease // J. Neurol. Sci. - 2017. - Vol. 289. - P. 49-54.
Eibenstein А., Fioretti A.B., Lena C. et al. Modern psychophysical tests to assess olfactory function // Neurol. Sci. - 2015. - Vol. 26. - P. 147-155.
Xu Y. Meta-analysis of risk factors for Parkinson's disease dementia.A 10-year study of the incidence of and factors predicting dementia in Parkinson’s disease / Xu Y., Yang J., Shang H. // Тranslational Neurodegeneration [Transl Neurodegener] – 2016 – Jun 01 –Vol. 5 –p. 11.
