COMPREHENSIVE REHABILITATION OF PATIENTS AFTER REMOVAL OF A POSTERIOR CRANIAL FOSSA TUMOR
Keywords:
posterior cranial fossa tumors, neurorehabilitation, cerebellar ataxia, cerebellar mutism, dysphagia, dysarthria, functional independence, quality of life, multidisciplinary approach.Abstract
Tumors of the posterior cranial fossa are among the most complex neuro-oncological diseases, as they are located in an anatomically confined space in close proximity to the cerebellum, brainstem, fourth ventricle, caudal group of cranial nerves and cerebrospinal fluid pathways. Even after technically successful surgical removal of the tumor, a significant proportion of patients retain coordination, motor, speech, bulbar, cognitive and psychoemotional disorders. The aim of the article is to provide a scientific rationale for comprehensive rehabilitation of patients after removal of posterior cranial fossa tumors, taking into account the early postoperative period, the structure of neurological deficit and functional prognosis. The article discusses the main components of neurorehabilitation: early verticalization, therapeutic physical training, vestibulo-coordination exercises, speech therapy correction, dysphagia therapy, neuropsychological support and occupational therapy. Special attention is paid to the assessment of recovery using the SARA, Berg Balance Scale, Barthel Index/FIM, MoCA and SF-36. It is shown that comprehensive rehabilitation contributes to the improvement of balance, gait, self-care, speech activity, swallowing, cognitive productivity and quality of life; however, in cases of severe posterior fossa syndrome, cerebellar mutism, brainstem involvement and aggressive oncological treatment, full recovery is not always achieved. It is concluded that the effectiveness of treatment of patients with posterior cranial fossa tumors is determined not only by the radicality of resection but also by the quality of subsequent staged neurorehabilitation.
References
Bartolo, M., Zucchella, C., Pace, A., Lanzetta, G., Vecchione, C., Grillea, G., Serrao, M., Tassorelli, C., Sandrini, G., & Pierelli, F. (2012). Early rehabilitation after surgery improves functional outcome in inpatients with brain tumours. Journal of Neuro-Oncology, 107, 537–544. doi:10.1007/s11060-011-0772-5
Chieffo, D., Lino, F., Arcangeli, V., Moriconi, F., Frassanito, P., Massimi, L., & Tamburrini, G. (2022). Posterior fossa tumor rehabilitation: An up-to-date overview. Children, 9(6), 904. doi:10.3390/children9060904
Decock, M., De Wilde, R., Van Der Looven, R., & Linden, C. (2022). Motor functioning and intelligence quotient in paediatric survivors of a fossa posterior tumor following a multidisciplinary rehabilitation program. International Journal of Environmental Research and Public Health, 19(12), 7083. doi:10.3390/ijerph19127083
Kasatkin, V., Deviaterikova, A., Shurupova, M., & Karelin, A. (2021). The feasibility and efficacy of short-term visual-motor training in pediatric posterior fossa tumor survivors. European Journal of Physical and Rehabilitation Medicine. doi:10.23736/S1973-9087.21.06854-4
Kasatkin, V., Romanova, E., Glebova, E., Deviaterikova, A., Tolchennikova, V., Sharapkova, A., Manukyan, P., Karpova, N., Sarkisyan, R., & Karelin, A. (2024). Effects of cognitive-motor intervention for pediatric posterior fossa tumor survivors: Results of a pilot study. Journal of Neuro-Oncology, 168, 57–67. doi:10.1007/s11060-024-04636-z
Krajewski, S., Furtak, J., Zawadka-Kunikowska, M., Kachelski, M., Soboń, J., & Harat, M. (2023). Functional state and rehabilitation of patients after primary brain tumor surgery for malignant and nonmalignant tumors: A prospective observational study. Current Oncology, 30, 5182–5194. doi:10.3390/curroncol30050393
Levin, J., Rosenberg, N., & Tsao, E. (2024). QOL-20. A review of the literature on the rehabilitation of patients with posterior fossa syndrome. Neuro-Oncology, 26, 0–0. doi:10.1093/neuonc/noae064.609
Matson, K., & Corr, G. (2024). NURS-06. Music therapy: An integral part of rehabilitation for cerebellar mutism syndrome. Neuro-Oncology, 26, 0–0. doi:10.1093/neuonc/noae064.654
O’Donovan, B., Kavanagh, N., Malone, A., Horgan, F., & Bennett, K. (2025). Rehabilitation needs of adults after a brain tumour diagnosis: A scoping review. PLOS One, 20. doi:10.1371/journal.pone.0325266
Pieczyńska, A., Pilarska, A., & Hojan, K. (2022). Predictors of functional outcomes in adults with brain tumor undergoing rehabilitation
treatment: A systematic review. European Journal of Physical and Rehabilitation Medicine, 58, 666–674. doi:10.23736/S1973-9087.22.07510-4
Raches, D., Ashford, J., Bryndziar, M., Mulé, T., Huggins, A., Lockett, S., Harris, A., Taylor, H., Bursi, E., Winfrey, R., Lynn, S., Gajjar, A., Robinson, G., & Conklin, H. (2023). Feasibility and perceived benefit of an interdisciplinary rehabilitation approach within a tertiary pediatric hematology/oncology setting. Journal of the International Neuropsychological Society, 29, 8–9. doi:10.1017/S1355617723000899
Sarvode, S., Dhaduk, R., Chen, Y., Taneja, S., Bass, J., Partin, R., Szymanek, K., Wogksch, M., Conklin, H., Raches, D., Merchant, T., Klimo, P., Gajjar, A., Krull, K., Khan, R., Armstrong, G., Ness, K., Robinson, G., Mirzaei, S., Brinkman, T., Hudson, M., & Phillips, N. (2026). Long-term outcomes associated with posterior fossa syndrome in survivors of childhood medulloblastoma. JAMA Network Open, 9. doi:10.1001/jamanetworkopen.2025.59376
Sleight, A., Gerber, L., Marshall, T., Livinski, A., Alfano, C., Harrington, S., Flores, A., Virani, A., Hu, X., Mitchell, S., Varedi, M., Eden, M., Hayek, S., Reigle, B., Kerkman, A., Neves, R., Jablonoski, K., Hacker, E., Sun, V., Newman, R., McDonnell, K., L’Hotta, A., Schoenhals, A., & Stout, N. (2022). A systematic review of functional outcomes in cancer rehabilitation research. Archives of Physical Medicine and Rehabilitation. doi:10.1016/j.apmr.2022.01.142
Tsetlina, V., Cassidy, D., Tenaglia, A., Levin, J., Tsao, E., & Ibanez, K. (2024). QOL-12. Lessons learned from longitudinal care in posterior fossa syndrome. Neuro-Oncology, 26, 0–0. doi:10.1093/neuonc/noae064.600
Weyer-Jamora, C., Brie, M., Luks, T., Smith, E., Hervey-Jumper, S., & Taylor, J. (2021). Postacute cognitive rehabilitation for adult brain tumor patients. Neurosurgery, 89, 945–953. doi:10.1093/neuros/nyaa552
Wu, J., Orme, P., & Quinn, S. (2024). Children and adolescents with posterior fossa tumors demonstrate excellent gains in inpatient rehabilitation. Archives of Physical Medicine and Rehabilitation. doi:10.1016/j.apmr.2024.02.080
Wu, J., Wishart, B., Cohen, S., Orme, P., Quinn, S., & Nimec, D. (2024). The Pediatric Physiatric Posterior Fossa Symptoms Scale (3PFSs): Impairments and outcome in pediatric inpatient rehabilitation for posterior fossa brain tumors. Neuro-Oncology. doi:10.1093/neuonc/noae199
Yu, J., Jung, Y., Park, J., Kim, J., Suh, M., Cho, K., & Kim, M. (2019). Intensive rehabilitation therapy following brain tumor surgery: A pilot study of effectiveness and long-term satisfaction. Annals of Rehabilitation Medicine, 43, 129–141. doi:10.5535/arm.2019.43.2.129
Khan, R. B., Patay, Z., Klimo, P., Huang, J., Kumar, R., Boop, F. A., Raches, D., Conklin, H., Sharma, R., Simmons, A., Sadighi, Z., Onar-Thomas, A., Gajjar, A., & Robinson, G. W. (2021). Clinical features, neurologic recovery, and risk factors of post-operative posterior fossa syndrome and delayed recovery: A prospective study. Neuro-Oncology, 23(9), 1586–1596. doi:10.1093/neuonc/noab030
Renne, B., Radic, J., Agrawal, D., Albrecht, B., Bonfield, C. M., Cohrs, G., Davis, T., Gupta, A., Hebb, A. L. O., Lamberti-Pasculli, M., Knerlich-Lukoschus, F., Lindsay, S., McNeely, P. D., Pillai, S., Rai, H. I. S., Sborov, K. D., Vitali, A., Walling, S., Woerdeman, P., … Steinbok,
P. (2020). Cerebellar mutism after posterior fossa tumor resection in children: A multicenter international retrospective study to determine possible modifiable factors. Child’s Nervous System, 36, 1159–1169. doi:10.1007/s00381-019-04058-7
Sala, F., Coppola, A., & Tramontano, V. (2015). Intraoperative neurophysiology in posterior fossa tumor surgery in children. Child’s Nervous System, 31, 1791–1806. doi:10.1007/s00381-015-2893-1
Packer, R. J., Zhou, T., Holmes, E., Vezina, G., & Gajjar, A. (2013). Survival and secondary tumors in children with medulloblastoma receiving radiotherapy and adjuvant chemotherapy. Journal of Clinical Oncology, 31(12), 1492–1498.
Thompson, E. M., Hielscher, T., Bouffet, E., Remke, M., Luu, B., Gururangan, S., McLendon, R. E., Bigner, D. D., Lipp, E. S., Perreault, S., Cho, Y. J., & Taylor, M. D. (2016). Prognostic value of medulloblastoma extent of resection after accounting for molecular subgroup: An integrated clinical and molecular analysis. The Lancet Oncology, 17(4), 484–495.