ПАРКИНСОН КАСАЛЛИГИ ВА ВАСКУЛЯР ПАРКИНСОНИЗМДА КОГНИТИВ ЎЗГАРИШЛАРНИНГ ГИПЕРКОРТИЗОЛЕМИЯ БИЛАН БОҒЛИҚЛИГИ
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Паркинсон касаллиги, васкуляр Паркинсонизм, Гиперкортизолемия, Кортизол гормони, когнитив бузилишлар, депрессия##article.abstract##
Паркинсон касаллиги бугунги кун неврологияси ва гериатриясининг долзарб мавзуларидан бири хисобланади. Бугунги кунда ушбу касалликнинг этиологияси, патогенези ва касаллик келтириб чиқараётган асоратлар хавфи чуқур ўрганилмоқда. . Клиник кузатувда жами 75 нафар бемор иштирок этди. Беморлар 3 гурухга бўлиб ўрганилди.биринчи гуруҳ паркинсон касаллиги бўлган беморлар, иккинчи гурух Васкуляр Паркинсонизм ташхиси бўлган беморлар, учинчи гуруҳ эса соғлом кўнгиллилар. Беморлардаги когнитив бузилишлар Logical Memory subtest 1 and 2, Wechsler Memory Scale Revised, Hamilton Rating Scale for Depression Гамилтон шкаласисини қўллаган ҳолда ўрганилди.
Барча беморларда эрталабки қон зардобида кортизол гормонининг концентрацияси иммунофлюрессент усулида аниқланди. Нопараметрик усуллар лабаратор тахлил натижаларини ва обьектив клиник маьлумотларни статистик қайта ишлаш учун қўлланилди. Р нинг кахамиятлилик даражаси 0.05 га тенг бўлди.
Паркинсон касаллиги ва Васкуляр Паркинсонизмда қон зардобида эрталабки кортизол концентрациясининг ўзгариши ва ривожланиб борувчи когнитив нуқсонлар орасида бевосита алоқалар мавжуд бўлиб, ушбу алоқалар бири бири билан узвий боғлиқ эканлиги аниқланди.
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