SURUNKALI UMUMLASHGAN PARODONTITNING ETIOPATOGENEZI VA KLINIK XUSUSIYATLARI BO‘YICHA ZAMONAVIY ILMIY QARASHLAR: ADABIYOTLAR SHARHI
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surunkali umumlashgan parodontit, etiopatogenez, biofilm, yallig‘lanish, mikrotsirkulyatsiya, suyak rezorbsiyasi, sitokinlar##article.abstract##
Ushbu sharh surunkali umumlashgan parodontitning etiopatogenezi va klinik xususiyatlariga oid zamonaviy ilmiy ma’lumotlarni umumlashtiradi. Surunkali umumlashgan parodontit ko‘p omilli immun-yallig‘lanish kasalligi bo‘lib, patogen anaerob biofilm va organizmning disbalanslangan immun javobi o‘zaro ta’siri natijasida rivojlanadi. To‘qimalarning yemirilishiga olib keluvchi asosiy mexanizmlar qatoriga mikrobiotsenozning buzilishi, yallig‘lanish sitokinlarining ortishi, oksidlovchi stress, mikrotsirkulyatsiya buzilishi hamda suyak remodellasiyasining izdan chiqishi kiradi.
Kasallikning klinik manzarasi gingivaning yallig‘lanishi, parodontal cho‘ntaklar chuqurlashuvi, birikish yo‘qolishi, alveolyar suyak rezorbsiyasi va tishlarning harakatchanligi bilan ifodalanadi. Adabiyotlar sharhida diabet, yurak-qon tomir kasalliklari, surunkali buyrak yetishmovchiligi kabi tizimli holatlar, shuningdek xulq-atvor omillari va anatomik xususiyatlarning kasallik og‘irligiga ta’siri ta’kidlangan. Ushbu mexanizmlarni chuqur tushunish diagnostika va davolash strategiyalarini takomillashtirish uchun muhimdir.
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